Surfactant Pharmacokinetics in the Eye
The ocular pharmacokinetics of benzalkonium chloride (BAK) and sodium lauryl sulfate (SLS) have been determined in neonatal, young, and adult rabbits. BAK is confined to the cornea and conjunctiva, while SLS distributes widely. After single- or multiple-drop administration, the order of accumulation is neonatal > young > adult eye. Multiple-drop administration leads to accumulation to a tissue dependent steady state. BAK and SLS alter membrane permeability and can alter protein profiles of neonatal cells in culture. Such changes may alter tissue growth and differentiation.
KeywordsAqueous Humor Sodium Lauryl Sulfate Corneal Epithelium Benzalkonium Chloride Adult Rabbit
Unable to display preview. Download preview PDF.
- Araie M, Tabase M, Sakai Y, Ishii Y, Yokoyama Y, and Kitagawa M (1982) Beta adrenergic blockers: Ocular penetration and binding to uveal pigment. Jap J Ophthalmol. 26: 248–263.Google Scholar
- Clayton RM, Green K, Wilson M, Zehir A, Jack J and Searle L (1985) The penetration of detergents into adult and infant eyes: Possible hazards of additives to ophthalmic preparations. Fd Chem Tox 23: 239–246.Google Scholar
- Patton TF (1977) Pediatric dosing considerations in ophthalmology: dosage adjustments based on aqueous humor volume ratio. J Ped Ophthalmol 14: 254–256.Google Scholar
- Tonjum AM (1977) Permeability of the rabbit corneal epithelium to horseradish peroxidase after the influence of benzalkonium chloride. Acta Ophthalmol (Kbh) 54: 335–347.Google Scholar