Abstract
The extent of absorption occurring from the instillation of drugs topically to the eye is severely limited by physiological constraints. Consequently, it is important to consider optimizing corneal penetration in the development of a new ophthalmic drug. For some drugs an increase in the penetration rate results in a dramatic increase in effect. However, for certain drugs other pharmacokinetic processes, i.e. distribution, may be more critical to increased effectiveness. Examples are presented.
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Schoenwald, R.D. (1987). The Importance of Optimizing Corneal Penetration. In: Saettone, M.F., Bucci, M., Speiser, P. (eds) Ophthalmic Drug Delivery. FIDIA Research Series, vol 11. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-4175-9_15
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DOI: https://doi.org/10.1007/978-1-4757-4175-9_15
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