Ocular Anatomy and Physiology: Its Relevance to Transcorneal Drug Absorption and to Vehicle Effects

  • M. Peduzzi
  • A. Debbia
  • A. Monzani
Part of the FIDIA Research Series book series (FIDIA, volume 11)


Owing to easy accessibility of the eyeball, topically applied drugs are widely employed in ophthalmology for both diagnostic and therapeutic purposes.


Corneal Epithelium Benzalkonium Chloride Drug Penetration Meibomian Gland Vehicle Effect 


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Suggested Readings

  1. Adler F.H.: Physiology of the eye, 4th edition, c.v. Mosby Co., St. Louis 1985, p. 42.Google Scholar
  2. Burstein N.L.: Corneal citotoxicity of topically applied drugs, vehicles and preservatives. Survey of Ophthalmol., 25 (1), 15, 1980.CrossRefGoogle Scholar
  3. Doane M.D., Jensen A.D., Dohlman H.: Penetration routes of topically applied eye medications. Am. J. Ophthalmol. 85, 383, 1978.PubMedGoogle Scholar
  4. Ellis P.P., Smith D.L.: Handbook of ocular therapeutics and pharmacology, 4th edition. c.v. Mosby Co., St. Louis 1983, p. 3.Google Scholar
  5. Gaster R.N., Leopold I.N.: Pharmacologic principles in the treatment of corneal disease. In: Biomedical Foundation of Ophthalmology, Duane T.D. and Jaeger E.A. Edts, Vol. III, Harper & Row Publishers, Philadelphia, 1982, p. 1.Google Scholar
  6. Havener W.H.: Ocular pharmacology, c.v. Mosby Co., St. Louis 1974, p. 19.Google Scholar
  7. Hogan M.J., Alvarado J.A., Weddel J.E.: Hystology of the human eye. An atlas and textbook. W.B. Saunders Co., Philadelphia 1971, p. 55.Google Scholar
  8. Jakobieck F.A.: Ocular anatomy, embriology and teratology, Harper & Row Publishers, Philadelphia 1982, p. 153.Google Scholar
  9. Klyce S.D.: Electrical profiles in the corneal epithelium. J. Physiol. 226, 407, 1972.PubMedGoogle Scholar
  10. Maurice D.M., Mishima S.: Ocular pharmacokinetics. In: Pharmacology of the Eye, M.L. Sears Ed., Springer Verlag 1984, p. 20.Google Scholar
  11. Maurice D.M.: The cornea and sclera in: The Eye, 3rd Edition, Dawson H. Ed., Vol.1B, Academic Press Orlando (Florida), 1984.Google Scholar
  12. Pfister R.R., Burstein N.: The effects of ophthalmic drugs, vehicles and preservatives on corneal epithelium: a scanning electron microscope study. Invest. Ophthalmol. 15, 246, 1981.Google Scholar
  13. Tonjum A.M., Green K.: The effect of benzalkonium chloride on the electropotential of the rabbit cornea. Acta Ophthalmol. 53, 348, 1975.Google Scholar
  14. Wine N.A., Gornall A.G., Basu P.K.: The ocular uptake of subconjunctivally injected C14 hydrocortisone. Am. J. Ophthalmol. 58, 362, 1964.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • M. Peduzzi
    • 1
  • A. Debbia
    • 1
  • A. Monzani
    • 1
  1. 1.Department of OphthalmologyUniversity of ModenaItaly

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