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Microglia and Aging in the Brain

  • Caleb E. Finch
  • Todd E. Morgan
  • Irina Rozovsky
  • Zhong Xie
  • Richard Weindruch
  • Tomas Prolla

Abstract

Microglial activation during normal aging in the CNS is puzzling. In general, microglial activation is associated with neuron death, blood-brain barrier disruption, or invading lymphocytes, whereas, as we shall discuss, there is little evidence for such changes during normal aging. Microglial age changes may also interact with Alzheimer’s disease, which increases markedly during aging, as well as with inflammatory processes of aging in peripheral tissues.

Keywords

Microglial Activation Senile Plaque Neurobiol Aging Perivascular Macrophage Outer Molecular Layer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Caleb E. Finch
  • Todd E. Morgan
  • Irina Rozovsky
  • Zhong Xie
  • Richard Weindruch
  • Tomas Prolla

There are no affiliations available

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