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Conformation-Dependent Recognition Sites

  • Klaus Kühn

Abstract

The integrin-mediated interaction of cells with laminins has recently been reviewed by Aumailley et al.1 In this chapter, the structural aspects of laminin integrin interaction will be emphasized. At least seven integrins have been identified which bind to laminin (Fig. 4.3.1). They were determined by using inhibiting antibodies, affinity chromatography and more recently, adherence of cells transfected with individual integrin α-subunits. The recognition sites within laminin-1 for the integrins were mapped to distinct regions and domains using defined proteolytic laminin fragments or more recently, using fragments expressed recombinantly. The most detailed investigations were carried out with laminin-1 from the murine EHS tumor.

Keywords

Recognition Site Triple Helix Coiled Coil Laminin Receptor Collagen Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media Dordrecht 1997

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  • Klaus Kühn

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