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Post-Ligand Binding Events: Outside-In Signaling Through the Integrins

  • Frank S. David
  • Andreas Kern
  • Eugene E. Marcantonio

Abstract

Though first identified based on their interaction with extracellular matrix (ECM) molecules, integrins clearly function as more than simply mechanical linkages between cells and the ECM. The earliest molecular biological inquiries into integrin function, in which many of the different a and 13 subunits were cloned and characterized, revealed that large numbers of different heterodimers are capable of recognizing the same ligand. This observation alone suggests that either there is a large amount of redundancy in the integrin family or different integrins which bind the same ligand can be distinguished on the basis of the intracellular signals they generate.

Keywords

Focal Adhesion Kinase Focal Adhesion Cytoplasmic Domain Focal Contact Integrin Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 1997

Authors and Affiliations

  • Frank S. David
  • Andreas Kern
  • Eugene E. Marcantonio

There are no affiliations available

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