Skip to main content
SpringerLink
Log in

Characteristics of Specific Radiopharmaceuticals

  • Chapter
Fundamentals of Nuclear Pharmacy

  • 316 Accesses

Abstract

In Chapter 6 the general principles of labeling methods, particularly iodination and 99mTc-labeling, have been discussed, and kit preparation for formulation of 99mTc-radiopharmaceuticals has been described. In this chapter the practical aspects of preparation, labeling yield, stability, storage conditions, and other characteristics of radiopharmaceuticals most commonly used in nuclear medicine will be discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 74.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References and Suggested Reading

  • Callahan RJ, Froelich JW, McKusick KA, et al. A modified method for the in vivo labeling of red blood cells with Tc-99m: concise communication. J Nucl Med. 1982; 23:315.

    PubMed  CAS  Google Scholar 

  • Dewanjee MK. The chemistry of 99mTc-labeled radiopharmaceuticals. Semin Nucl Med. 1990; XX : 5.

    Google Scholar 

  • Ege GN, Warbick A. Lymphoscintigraphy: a comparison of Tc-99m antimony sulfide and Tc-99m stannous phytate. Br J Radiol. 1979; 53 : 124.

    Article  Google Scholar 

  • Fritzberg AR, Kasina S, Eshima D, et al. Synthesis and biological evaluation of technetium-99m MAG3 as hippuran replacement. J Nucl Med. 1986; 27 :11.

    Google Scholar 

  • Hamacher K, Coenen HH, Stocklin G. Efficient stereospecific synthesis of NCA 2-[18F]-fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution. J Nucl Med. 1986; 27 : 235.

    PubMed  CAS  Google Scholar 

  • Hnatowich DJ. Recent developments in the radiolabeling of antibodies with iodine, indium and technetium. Semin Nucl Med. 1990; XX : 80.

    Google Scholar 

  • Köhler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature. 1975; 256 : 495.

    Article  PubMed  Google Scholar 

  • Loberg MD, Cooper M, Harvey E, et al. Development of new radiopharmaceutical based on N-substitution of iminodiacetic acid. J Nucl Med. 1976; 17 : 633.

    PubMed  CAS  Google Scholar 

  • Nunn AD. Radiopharmaceutical for imaging myocardial perfusion. Semin Nucl Med. 1990; XX: 111.

    Google Scholar 

  • Package inserts of various kits available from commercial suppliers.

    Google Scholar 

  • Peters AM, Danpure HJ, Osman S, et al. Clinical experience with 99mTchexamethyl propylene amine oxime for labeling leukocytes and imaging inflammation. Lancet. 1986; 2 : 946.

    Article  PubMed  CAS  Google Scholar 

  • Smith TD, Richards P. A simple kit for the preparation of Tc-99m red blood cells. J Nucl Med. 1976; 17 : 126.

    PubMed  CAS  Google Scholar 

  • Sodd VJ, Allen DR, Hoagland DR, et al., eds. Radiopharmaceuticals II. New York: Society of Nuclear Medicine; 1979.

    Google Scholar 

  • Srivastava SC, Straub RF. Blood cell labeling with 99mTc: progress and perspectives. Semin Nucl Med. 1990; XX : 41.

    Google Scholar 

  • ten Berge RJM, Natarajan AT, Hardenman MR, et al. Labeling with indium-111 has detrimental effects on human lymphocytes. J Nucl Med. 1983; 24 : 615.

    PubMed  Google Scholar 

  • Thakur ML, Coleman RE, Welch MJ. Indium-111-labeled leukocytes for the localization of abscesses: preparation, analysis, tissue distribution and comparison with gallium-67 citrate in dogs. J Lab Clin Med. 1977; 82 : 217.

    Google Scholar 

  • Troutner DR, Volkert WA, Hoffman TJ, et al. A neutral lipophilic complex of Tc-99m with a multidentate amine oxime. Int J Appl Rad Isot. 1984; 35 : 467.

    Article  CAS  Google Scholar 

  • U.S. Pharmacopeia XXII. United States Pharmacopeial Convention, Rockville, Md; 1990.

    Google Scholar 

  • Walovitch RC, Hill TC, Garrity ST, et al. Characterization of technetium-99mL,L-ECD for brain perfusion imaging, Part 1: Pharmacology of technetium-99m ECD in nonhuman primates. J Nucl Med. 1989; 30 : 1892.

    PubMed  CAS  Google Scholar 

  • Welch MJ, ed. Radiopharmaceuticals and other compounds labelled with shortlived radionuclides. New York: Pergamon Press; 1977.

    Google Scholar 

  • Zuckier LS, Rodriguez LD, Scharff MD. Immunologic and pharmacologic concepts of monoclonal antibodies. Semin Nucl Med. 1990; XX: 166.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Nuclear Medicine, The Cleveland Clinic Foundation, 44195, Cleveland, OH, USA

    Gopal B. Saha Ph.D. (Director of Nuclear Chemistry and Pharmacy)

Authors
  1. Gopal B. Saha Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer Science+Business Media New York

About this chapter

Cite this chapter

Saha, G.B. (1992). Characteristics of Specific Radiopharmaceuticals. In: Fundamentals of Nuclear Pharmacy. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-4027-1_7

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-4027-1_7

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-4029-5

  • Online ISBN: 978-1-4757-4027-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation