In Vitro and In Vivo Nonimaging Tests

  • Gopal B. Saha


The radioimmunoassay (RIA) method was first developed by S.A. Berson and RS. Yalow in the late 1950s for the determination of insulin in human serum. Presently, the method is employed extensively to determine numerous hormones, enzymes, and drugs in minute quantities (10-9-10-12 M) in human plasma in order to assess various disease conditions. The general term for this method in both immune and nonimmune systems is the competitive binding assay (CBA).


Pernicious Anemia Competitive Binding Assay Free Antigen Label Antigen Schilling Test 
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Suggested Reading

  1. Andrews JT, Milne MJ (1977) Nuclear medicine. Wiley, New YorkGoogle Scholar
  2. Chase GC, Rabinowitz JL (1970) Principles of radioisotope methodology, 3rd ed, Burgess, MinneapolisGoogle Scholar
  3. Hayes RL, Goswitz FA, Pearson Murphy BE (eds) (1972) Radioisotopes in medicine: In vitro studies. CONF-671111. US Atomic Energy Commission, Oak RidgeGoogle Scholar
  4. Kirkham KD, Hunter WM (1971) Radioimmunoassay methods. Williams & Wilkins, BaltimoreGoogle Scholar
  5. Moss AJ Jr, Dalrymple GV, Boyd CM (eds) (1976) Practical radioimmunoassay. Mosby, St LouisGoogle Scholar
  6. Odell WD, Daughaday WH (eds) (1974) Principles of competitive protein-binding assays. Lippincott, PhiladelphiaGoogle Scholar
  7. Rothfeld B (ed) (1974) Nuclear medicine in vitro. Lippincott, PhiladelphiaGoogle Scholar
  8. Thorell JI, Larson SM (1978) Radioimmunoassay and related techniques. Mosby, St LouisGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Gopal B. Saha
    • 1
  1. 1.College of PharmacyUniversity of New MexicoAlbuquerqueUSA

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