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Dementia, Delirium, and Coma

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Family Medicine
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Abstract

Alterations in mental status ranging from mild forgetfulness and confusion to full-blown delirium and coma are common clinical problems in primary care. Studies1–3 have shown that 15% to 30% of hospitalized elderly patients experience delirium, and more than 40% of individuals over age 90 suffer from dementing illness. The enlarging elderly population combined with the aging brain’s exquisite vulnerability to changes in physiologic milieu accounts for this formidable prevalence of patients with disturbed cognitive (cerebral) function. This chapter addresses the clinical approach to the syndromes of dementia, delirium, and coma. Because the underlying causes of these syndromes are myriad and the clinical presentations so varied, physicians are faced with an imposing diagnostic challenge that requires a systematic and disciplined approach.

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References

  1. Lipowski ZJ. Delirium in the elderly patient. N Engl J Med 1989;320:578–82.

    Article  PubMed  CAS  Google Scholar 

  2. Lipowski ZJ. Delirium (acute confusional states). JAMA 1987; 258:1789–92.

    Article  PubMed  CAS  Google Scholar 

  3. Evans DA, Funkenstein HH, Albert MS, et al. Prevalence of Alzheimer’s disease in a community population of older persons is higher than previously reported. JAMA 1989;262:2551–6.

    Article  PubMed  CAS  Google Scholar 

  4. Crook TH. Diagnosis and treatment of normal and pathologic memory impairment in later life. Semin Neurol 1989;9:20–30.

    Article  PubMed  Google Scholar 

  5. Council on Scientific Affairs. Dementia. JAMA 1986;256:2234–8.

    Article  Google Scholar 

  6. Cummings JL, Benson DF. Dementia: a clinical approach. 2nd ed. Boston: Butterworth, 1992.

    Google Scholar 

  7. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders. 3rd rev. ed. Washington, DC: American Psychiatric Association, 1987.

    Google Scholar 

  8. Clarfield AM. The reversible dementias: do they reverse? Ann Intern Med 1988;109:476–86.

    Article  PubMed  CAS  Google Scholar 

  9. Barry PP, Moskowitz MA. The diagnosis of reversible dementia in the elderly: a critical review. Arch Intern Med 1988;148:1914–8.

    Article  PubMed  CAS  Google Scholar 

  10. O’Brien JG. Evaluation of acute confusion (delirium). Prim Care 1989;16:349–60.

    PubMed  Google Scholar 

  11. Plum F, Posner J. Diagnosis of stupor and coma. 3 rd ed. Philadelphia: Davis, 1980.

    Google Scholar 

  12. Harris JO, Berger JR. Clinical approach to stupor and coma. In: Bradley WG, Daroff RB, Fenichel GM, Marsden CD, editors. Neurology in clinical practice. Boston: Butterworth, 1991:43–63.

    Google Scholar 

  13. National Institutes of Health Consensus Conference. Differential diagnosis of dementing disease. JAMA 1987;258:3411–16.

    Article  Google Scholar 

  14. Organizing Committee, Canadian Consensus Conference on the Assessment of Dementia. Assessing dementia—the Canadian consensus. Can Med Assoc J 1991;144:851–5.

    Google Scholar 

  15. Ramsdell JW, Rothrock JF, Werd HW, Volk DM. Evaluation of cognitive impairment in the elderly. J Gen Intern Med 1990;5:55–66.

    Article  PubMed  CAS  Google Scholar 

  16. Siu AL. Screening for dementia and investigating its causes. Ann Intern Med 1991;115:122–32.

    Article  PubMed  CAS  Google Scholar 

  17. Wells CE. Pseudodementia. Am J Psychiatry 1979;36:895–900.

    Google Scholar 

  18. Reifler BV, Larson E, Teri L, Poulsen M. Dementia of the Alzheimer’s type and depression. J Am Geriatr Soc 1986;34:855–9.

    PubMed  CAS  Google Scholar 

  19. Hachinski VC. Multi-infarct dementia. Neurol Clin 1983;1:27–36.

    PubMed  CAS  Google Scholar 

  20. Nelson A, Fogel B, Faust D. Bedside cognitive screening instruments. J Nerv Ment Dis 1986;174:73–83.

    Article  PubMed  CAS  Google Scholar 

  21. Folstein M, Folstein S, McHugh P. Mini-mental state—a practical method for grading the cognitive state of patients for the clinician. J Psychiatry Res 1975;12:187–98.

    Article  Google Scholar 

  22. Naugle RI, Kawcyak K. Limitations of the mini-mental state exam. Cleve Clin J Med 1989;56:277–81.

    PubMed  CAS  Google Scholar 

  23. Ho DD, Bredlsen DE, Vinters HV, Daar ES. The acquired immunodeficiency syndrome (AIDS) dementia-complex. Ann Intern Med 1989;111:400–10.

    Article  PubMed  CAS  Google Scholar 

  24. Teasdale G, Jennett B. Assessment of coma and impaired consciousness—a practical scale. Lancet 1974;2:81–86.

    Article  PubMed  CAS  Google Scholar 

  25. Larson EB, Reifler BV, Sumi SM, et al. Diagnostic tests in the evaluation of dementia: a prospective study of 200 elderly outpatients. Arch Intern Med 1986;146:1917–22.

    Article  PubMed  CAS  Google Scholar 

  26. Jagust WJ, Eberling JL. MRI, CT, SPECT, PET: their use in diagnosing dementia. Geriatrics 1991;46:28–35.

    PubMed  CAS  Google Scholar 

  27. Larson EB, Lo B, Williams ME. Evaluation and care of elderly patients with dementia. J Gen Intern Med 1986;1:116–26.

    Article  PubMed  CAS  Google Scholar 

  28. Winograd CH, Jarvik LF. Physician management of the dementia patient. J Am Geriatr Soc 1986;34:288–308.

    Google Scholar 

  29. Meyer JS, Judd BW, Tawakina T, Rogers RL, Mortel KF. Improved cognition after control of risk factors for multi-infarct dementia. JAMA 1986;256:2203–13.

    Article  PubMed  CAS  Google Scholar 

  30. Omnibus Budget Reconciliation Act 1987. Washington, DC: US Government Printing Office, 1989.

    Google Scholar 

  31. Mace NL, Rabins PV. The 36 hour day: a family guide to caring for persons with Alzheimer’s disease, related dementia illnesses, and memory loss in late life. 2 nd ed. Baltimore: Johns Hopkins Press, 1991.

    Google Scholar 

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© 1994 Springer Science+Business Media New York

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Celestino, F.S. (1994). Dementia, Delirium, and Coma. In: Taylor, R.B. (eds) Family Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-4005-9_64

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  • DOI: https://doi.org/10.1007/978-1-4757-4005-9_64

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-4007-3

  • Online ISBN: 978-1-4757-4005-9

  • eBook Packages: Springer Book Archive

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