Fever of unknown origin (FUO) is a classic term from the internal medicine literature that continues to present an interesting diagnostic challenge. However, the classic approach and definition described in the literature over the last 30 years is no longer practical. Family physicians should be able to define the changes in the etiologies of FUOs over the years, list the new ambulatory definition of an FUO, and carry out an appropriate evaluation of a suspected FUO in the ambulatory practice setting.
KeywordsInfective Endocarditis Familial Mediterranean Fever Unknown Origin Undetermined Origin Normal Diurnal Variation
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