Endometrial Carcinoma

  • Michael T. Mazur
  • Robert J. Kurman


Endometrial adenocarcinoma is the most common malignant tumor of the female genital tract in the United States. This neoplasm represents a biologically and morphologically diverse group of tumors, with differing pathogenesis.1–3 The typical endometrial adenocarcinoma is well to moderately differentiated, with or without squamous differentiation, and accounts for 80% to 85% of all endometrial carcinomas. The typical patient is perimenopausal or postmenopausal, obese, hypertensive, and diabetic. The low-grade tumors are frequently associated with hyperplasia, especially atypical hyperplasia, conditions that result from unopposed estrogenic stimulation. Unopposed estrogenic stimulation due to anovulatory cycles normally occurs at the time of menopause or in younger women with the Stein-Leventhal syndrome.


Endometrial Carcinoma Nuclear Grade Clear Cell Carcinoma Mucinous Carcinoma Serous Carcinoma 


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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Michael T. Mazur
    • 1
  • Robert J. Kurman
    • 2
    • 3
  1. 1.Crouse Irving Memorial Hospital, Health Science CenterState University of New YorkSyracuseUSA
  2. 2.Departments of Gynecology and Obstetrics and PathologyThe Johns Hopkins HospitalBaltimoreUSA
  3. 3.The Johns Hopkins University School of MedicineBaltimoreUSA

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