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Sarcoidosis

  • Yale Rosen

Abstract

Sarcoidosis is a systemic disease that involves the lungs in almost all afflicted individuals. The pathologist plays a major and essential role in the management of patients with sarcoidosis because definitive establishment of the diagnosis is dependent on the microscopic examination of tissue. The nature of this enigmatic disease has perplexed physicians since the first description of its histologic features by Boeck in 1905. Interest in sarcoidosis has stimulated an enormous amount of research into its etiology, pathogenesis, epidemiology, abnormalities of the immune system, and clinical aspects. These efforts have resulted in thousands of publications1,2 and 10 international conferences on sarcoidosis and other granulomatous disorders.3–5 Yet, despite the substantial increase in knowledge about the various aspects of sarcoidosis gained over the past 100 years, its etiology remains entirely unknown. Many excellent publications present comprehensive and updated coverage of its immunological, clinical and radiographic features, epidemiology, abnormal physiology, diagnostic modalities, and treatment.6–9a

Keywords

Mononuclear Phagocyte Epithelioid Cell Open Lung Biopsy Pulmonary Sarcoidosis Chronic Beryllium Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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  • Yale Rosen

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