Insulin Secretion in Type II Diabetes Mellitus

  • Yogish C. Kudva
  • Peter C. Butler
Part of the Contemporary Biomedicine book series (CB, volume 15)


Noninsulin-dependent diabetes mellitus (NIDDM) is characterized by both impaired insulin secretion and action (1). Insulin secretion is abnormal in first-degree relatives of patients with NIDDM with normal (2) or abnormal (3) glucose tolerance. This implies that defective insulin secretion is present early and plays a primary role in the pathogenesis of NIDDM. Since it is clear that there is a molecular genetic basis for NIDDM, the question arises regarding whether the mutations that predispose an individual to NIDDM are related to insulin action or insulin secretion.


Insulin Secretion Plasma Insulin Concentration Islet Amyloid Polypeptide Glucokinase Gene Sulin Secretion 


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© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Yogish C. Kudva
  • Peter C. Butler

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