Nonspecific Tumors of the Ovary, Including Mesenchymal Tumors and Malignant Lymphoma

  • Aleksander Talerman


The tumors discussed in this chapter comprise a heterogeneous group of neoplasms that are not specific to the ovary. They are uncommon in this location, occurring much more frequently in other parts of the body. Consequently, whenever they are encountered in the ovary, these tumors pose difficult problems in diagnosis, histogenesis, behavior, and therapy for the pathologist and clinician. These neoplasms must be differentiated from primary ovarian neoplasms containing mesenchymal tissue, as well as from metastatic and disseminated neoplasms affecting the ovary. Thus, mesenchymal neoplasms nonspecific to the ovary must be differentiated primarily from teratomatous neoplasms containing large amounts of mature or immature mesenchymal elements and from the mixed müllerian (mesodermal) tumors (MMMT), composed of different malignant connective tissue elements. In contrast, the primary malignant lymphomas must be differentiated from the more common disseminated malignant lymphoma and leukemia, which not infrequently affect the ovary. These two different groups of neoplasms—the connective tissue neoplasms nonspecific to the ovary and malignant lymphoma of the ovary—although included under the same heading, are discussed separately because of their different nature, behavior, and histogenesis. In addition, the adenomatoid tumor, which is of mesothelial origin, the ovarian tumor of probable wolffian origin, ovarian neoplasms of neural origin, hepatoid carcinoma of the ovary, and small cell carcinoma of the ovary with pulmonary differentiation also are included.


Ovarian Tumor Small Cell Carcinoma Granulosa Cell Tumor Granulocytic Sarcoma Malignant Peritoneal Mesothelioma 


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  1. 1.
    Abell MR, Holtz F (1965) Ovarian neoplasms in childhood and adolescence. 2. Tumors of non-germ cell origin. Am J Obstet Gynecol 93: 850PubMedGoogle Scholar
  2. 2.
    Azoury RS, Woodruff JD (1971) Primary ovarian sarcomas. Report of 43 cases from the Emil Novak Ovarian Tumor Registry. Obstet Gynecol 37: 920PubMedGoogle Scholar
  3. 3.
    Balaton A, Vaury P, Imbert MC, Mussy MA (1987) Primary leiomyosarcoma of the ovary. A histological and immunocy-tochemical study. Gynecol Oncol 28: 116PubMedCrossRefGoogle Scholar
  4. 4.
    Ballon SC, Donaldson RC, Berman ML, Swanson GA, Byron RL (1978) Myeloblastoma (granulocytic sarcoma) of the ovary. Arch Pathol Lab Med 102: 474PubMedGoogle Scholar
  5. 5.
    Bambirra EA, Miranda D, Magalhaes GMC (1982) Plasma cell myeloma simulating Krukenberg’s tumor. South Med J 75: 511PubMedCrossRefGoogle Scholar
  6. 6.
    Bare WW, McCloskey JF (1961) Primary Hodgkin’s disease of the ovary. Obstet Gynecol 17: 447Google Scholar
  7. 7.
    Berard C, O’Conor GT, Thomas LB, Torloni H (1969) Histopathological classification of Burldtt’s tumour. Bull WHO 40: 601Google Scholar
  8. 8.
    Biggart JH, Macafee CHG (1955) Tumours of ovarian mesenchyme. A clinico-pathological survey. J Obstet Gynaecol Br Emp 62: 829PubMedCrossRefGoogle Scholar
  9. 9.
    Bower JF, Erikson ER (1967) Bilateral ovarian fibroma in a 5 year old. Am J Obstet Gynecol 99: 880PubMedGoogle Scholar
  10. 10.
    Brady K, Page DV, Benn LE, de las Morenas A, O’Brien M (1987). Ovarian myxoma. Am J Obstet Gynecol 156: 1240.PubMedGoogle Scholar
  11. 11.
    Braithwaite J (1894) On atrophy with collapse (cirrhosis), fibroid degeneration, angioma of the ovaries. Trans Obstet Soc London 36: 235Google Scholar
  12. 12.
    Brew DS, Jackson JG (1960) Lymphosarcoma of the ovary in young African girls. Br J Cancer 14: 621PubMedCrossRefGoogle Scholar
  13. 13.
    Burket RL, Rauh JL (1976) Gorlin’s syndrome. Ovarian fibromas at adolescence. Obstet Gynecol 47: 43SPubMedGoogle Scholar
  14. 14.
    Burldtt DP, Wright DH (1970) Burldtt’s lymphoma. Edinburgh, Livingstone.Google Scholar
  15. 15.
    Cecalupo AJ, Frankel LS, Sullivan MP (1982) Pelvic and ovarian extramedullary leukemic relapse in young girls. A report of four cases and review of the literature. Cancer 50: 587PubMedCrossRefGoogle Scholar
  16. 16.
    Chan YF, Leung CS, Ma L (1989) Primary embryonal rhabdomyosarcoma of the ovary in a 4-year-old girl. Histopathology 15: 211CrossRefGoogle Scholar
  17. 17.
    Charache H (1959) Ovarian tumors in childhood. Arch Surg 79: 573PubMedCrossRefGoogle Scholar
  18. 18.
    Chorlton I, Noms HJ, King FM (1974) Malignant reticu-loendothelial disease involving the ovary as a primary manifestation. A series of 19 lymphomas and 1 granulocytic sarcoma. Cancer 34: 397PubMedCrossRefGoogle Scholar
  19. 19.
    Clendenning WE, Herdt JR, Black JB (1963) Ovarian fibromas and mesenteric cysts. Their association with hereditary basal cell cancer of the skin. Am J Obstet Gynecol 87: 1008PubMedGoogle Scholar
  20. 20.
    Climie AR, Heath LP (1968) Malignant degeneration of benign cystic teratoma of the ovary. Review of the literature and report of a chondrosarcoma and a carcinoid tumor. Cancer 22: 824PubMedCrossRefGoogle Scholar
  21. 21.
    De Franchis M, Galliani F (1964) Nurinoma del ovario. Riv Patol Clin 19: 567Google Scholar
  22. 22.
    Dickersin GR, Kline IW, Scully RE (1982) Small cell carcinoma of the ovary with hypercalcemia. A report of eleven cases. Cancer 49: 188PubMedCrossRefGoogle Scholar
  23. 23.
    Dockerty MB, Masson JC (1944) Ovarian fibromas: A clinical and pathologic study of two hundred eighty three cases. Am J Obstet Gynecol 47: 741Google Scholar
  24. 24.
    Dorfman FR (1965) Childhood lymphoma in St. Louis, Missouri, clinically and histologically resembling Burldtt’s tumor. Cancer 18: 418PubMedCrossRefGoogle Scholar
  25. 25.
    Dover H (1950) Neurofibrosarcoma of the ovary, associated with neurofibromatosis. Can Med Assoc J 63: 488PubMedGoogle Scholar
  26. 26.
    Dutz W, Stout AP (1961) The myxoma in childhood. Cancer 14: 629PubMedCrossRefGoogle Scholar
  27. 27.
    Ebrahimi T, Goldsmith JW, Okagaki T (1971) Hemangioma of the ovary. A case report. Obstet Gynecol 38: 677PubMedGoogle Scholar
  28. 28.
    Eichhorn JH, Scully RE (1991). Ovarian myxoma. Clinicopathologic and immunocytologic analysis of five cases and a review of the literature. Int J Gynecol Pathol 10: 156.PubMedCrossRefGoogle Scholar
  29. 29.
    Eichhorn JH, Young RH, Scully RE (1992). Primary ovarian small cell carcinoma of pulmonary type. A clinico-pathologic, immunohistologic and flow cytometric analysis of 11 cases. Am J Surg Pathol 16: 926.PubMedCrossRefGoogle Scholar
  30. 30.
    Ewing J (1940) Neoplastic diseases, 4th ed. Philadelphia, Saunders.Google Scholar
  31. 31.
    Fallahzadeh H, Dockerty MB, Lee RA (1972) Leiomyoma of the ovary. Report of five cases and review of the literature. Am J Obstet Gynecol 113: 394PubMedGoogle Scholar
  32. 32.
    Fawcett FJ, Kimbell NKB (1971) Phaeochromocytoma of the ovary. J Obstet Gynaecol Br Commonw 78: 458PubMedCrossRefGoogle Scholar
  33. 33.
    Ferenczy A, Fenoglio CM, Richart RM (1972) Observations on benign mesothelioma of the genital tract (adenomatoid tumor). Cancer 30: 244PubMedCrossRefGoogle Scholar
  34. 34.
    Ferry JA, Young RH (1991) Malignant lymphoma, pseudolymphoma and hematopoietic disorders of the female genital tract. Pathol Annu 26: 227PubMedGoogle Scholar
  35. 35.
    Fox H, Langley FA (1976) Tumours of the ovary. London, William Heinemann.Google Scholar
  36. 36.
    Fox H, Langley FA, Govan ADT, Hill AS, Bennett MM (1988) Malignant lymphoma presenting as an ovarian tumor. A clinicopathologic analysis of 34 cases. Br J Obstet Gynecol 95: 386CrossRefGoogle Scholar
  37. 37.
    Fundaro P (1969) Emangioma cavernoso bilaterale dell ovaia: Presentazione di un caso e rassegna della literatura. Folia Hered Patol 18: 45Google Scholar
  38. 38.
    Gay RM, Janovski NA (1969) Cavernous hemangioma of the ovary. Gynaecologia 168: 248PubMedGoogle Scholar
  39. 39.
    Gerbie AB, Hirsch MR, Greene RR (1955) Vascular tumors of the female genital tract. Obstet Gynecol 6: 499PubMedGoogle Scholar
  40. 40.
    Guérard MJ, Arguelles MA, Ferenczy A (1983) Rhabdomy-osarcoma of the ovary. Ultrastructural study of a case and review of the literature. Gynecol Oncol 15: 325PubMedCrossRefGoogle Scholar
  41. 41.
    Hart WR, Abell MR (1970) Adipose prosoplasia of the ovary. Am J Obstet Gynecol 106: 929PubMedGoogle Scholar
  42. 42.
    Hautzer NW (1984) Primary plasmacytoma of ovary. Gynecol Oncol 18: 115PubMedCrossRefGoogle Scholar
  43. 43.
    Hegg CA, Flint A (1990) Neurofibroma of the ovary. Gynecol Oncol 37: 437PubMedCrossRefGoogle Scholar
  44. 44.
    Howell CG, Rogers DA, Gable DS, Falls GD (1990) Bilateral ovarian fibromas in children. J Pediatr Surg 25: 690PubMedCrossRefGoogle Scholar
  45. 45.
    Hughesdon PE (1982) Ovarian tumors of wolffian or allied nature. Their place in ovarian oncology. J Clin Pathol 35: 526PubMedCrossRefGoogle Scholar
  46. 46.
    Ishikura H, Scully RE (1987) Hepatoid carcinoma of the ovary. A newly described tumor. Cancer 60: 2775PubMedCrossRefGoogle Scholar
  47. 47.
    Ishikura H, Fukasawa Y, Ogasawara K, Natori T, Tsukada Y, Aizawa M (1985) An AFP-producing gastric carcinoma with featurs of hepatoid differentiation. A case report. Cancer 56: 840PubMedCrossRefGoogle Scholar
  48. 48.
    Ishikura H, Kirimoto K, Shamoto M, et al (1986) Hepatoid adenocarcinomas of the stomach. An analysis of seven cases. Cancer 58: 119PubMedCrossRefGoogle Scholar
  49. 49.
    Janovski NA, Paramanandhan TL (1973) Ovarian tumors. Tumors and tumor-like conditions of the ovaries, fallopian tubes, and ligaments of the uterus. Philadelphia, W Saunders.Google Scholar
  50. 50.
    Kalstone CE, Jaffe RB, Abell MR (1969) Massive edema of the ovary simulating fibroma. Obstet Gynecol 34: 564PubMedGoogle Scholar
  51. 51.
    Kandalaft PL, Esteban JM (1992) Bilateral massive ovarian leiomyomata in a young woman. A case report with review of the literature. Mod Pathol 5: 586PubMedGoogle Scholar
  52. 52.
    Kannerstein M, Churg J (1977) Peritoneal mesothelioma. Hum Pathol 8: 83PubMedCrossRefGoogle Scholar
  53. 53.
    Kariminejad MH, Scully RE (1973) Female adnexal tumor of probable wolffian origin. Cancer 31: 671PubMedCrossRefGoogle Scholar
  54. 54.
    Kraemer BB, Silva EG, Sneige N (1984) Fibrosarcoma of the ovary. A new component in the nevoid basal-cell carcinoma syndrome. Am J Surg Pathol 8: 231PubMedCrossRefGoogle Scholar
  55. 55.
    Lawhead RA, Copeland LJ, Edwards CL (1985) Bilateral ovarian hemangiomas associated with diffuse abdominopelvic hemangiomatosis. Obstet Gynecol 65: 597PubMedGoogle Scholar
  56. 56.
    Long JP, Patchefsky AS (1971) Primary Hodgkin’s disease of the ovary. Obstet Gynecol 38: 680PubMedGoogle Scholar
  57. 57.
    Lorentzen M (1980) Giant cell tumor of the ovary. Virch Arch [Pathol Anat] 388: 113CrossRefGoogle Scholar
  58. 58.
    Lukes RJ, Collins RD (1974) Immunologic characterization of human malignant lymphomas. Cancer 34: 1488PubMedCrossRefGoogle Scholar
  59. 59.
    Lyday RO (1952) Fibroma of the ovary with abdominal implants. Am J Surg 84: 737PubMedCrossRefGoogle Scholar
  60. 60.
    Majmudar B, Kapernick PS, Phillips RS (1978) Ovarian myxoma. Hum Pathol 9: 723PubMedCrossRefGoogle Scholar
  61. 61.
    Mann LS, Metrick S (1961) Hemangioma of the ovary. Report of a case. J Int Coll Surg 36: 500PubMedGoogle Scholar
  62. 62.
    Martins SM, Klinger OJ (1964) Bilateral ovarian fibromas before the menarche. Am J Obstet Gynecol 87: 386Google Scholar
  63. 63.
    Masubuchi K, Kimura M, Suzuki H, Suzuki P, Aoki M (1970) Case of ovarian myxoma. Jpn J Cancer Clin 16: 156Google Scholar
  64. 64.
    Matamala MF, Nogales FF, Aneiros J, Heraiz MA, Caracuel MD (1988) Leiomyomas of the ovary. Int J Gynecol Pathol 7: 190PubMedCrossRefGoogle Scholar
  65. 65.
    McBurney RC, Trumbull M (1955) Hemangioma of the ovary with ascites. Miss Doct 32: 271PubMedGoogle Scholar
  66. 66.
    Meyer R (1943) Nerve tumors of the female genitals and pelvis. Arch Pathol 36: 437Google Scholar
  67. 67.
    Michael CA (1966) Pelvic fibroma causing recurrent attacks of hypoglycaemia in a post-menopausal patient. Proc Roy Soc Med 59: 835Google Scholar
  68. 68.
    Miles PA, Kiley KC, Mena H (1985) Giant fibrosarcoma of the ovary. Int J Gynecol Pathol 4: 83PubMedCrossRefGoogle Scholar
  69. 69.
    Mira JL (1991) Lipoleiomyoma of the ovary. Report of a case and review of the English literature. Int J Gynecol Pathol 10: 198PubMedCrossRefGoogle Scholar
  70. 70.
    Mishura VI (1963) Report of large benign tumor—report of three cases. Vopr Onkol 9: 103Google Scholar
  71. 71.
    Monterosso V, Jaffe ES, Merino MJ, Medeiros LJ (1993). Malignant lymphomas involving the ovary. A clinicopathologic analysis of 39 cases. Am J Surg Pathol 17: 154CrossRefGoogle Scholar
  72. 72.
    Morgan ER, Labotka RJ, Gonzalez-Crussi F, Wiederhold M, Sherman JO (1981) Ovarian granulocytic sarcoma as a primary manifestation of acute infantile myelomonocytic leukemia. Cancer 48: 1819PubMedCrossRefGoogle Scholar
  73. 73.
    Nelson GA, Dockerty MB, Pratt JH, Re-Mine WH (1958) Malignant lymphoma involving the ovaries. Am J Obstet Gynecol 76: 861PubMedGoogle Scholar
  74. 74.
    Nieminen U, von Numers C, Purola E (1969) Primary sarcoma of the ovary. Acta Obstet Gynecol Scand 48: 423PubMedCrossRefGoogle Scholar
  75. 75.
    Nogales FF (1982) Primary chondroma of the ovary. Histopathology 6: 376CrossRefGoogle Scholar
  76. 76.
    Nunez C, Abboud SL, Lemon NC, Kemp JA (1983) Ovarian rhabdomyosarcoma presenting as leukemia. Case report. Cancer 52: 297PubMedCrossRefGoogle Scholar
  77. 77.
    O’Conor GT (1961) Malignant lymphoma in African children. II. A pathological entity. Cancer 14: 270PubMedCrossRefGoogle Scholar
  78. 78.
    O’Conor GT, Rappaport H, Smith EB (1965) Childhood lymphoma resembling “Burkitt tumor” in the United States. Cancer 18: 411PubMedCrossRefGoogle Scholar
  79. 79.
    Okamura H, Virutamasen P, Wright KH, Wallach EE (1972) Ovarian smooth muscle in the human being, rabbit, and cat: Histochemical and electron microscopic study. Am J Obstet Gynecol 112: 183PubMedGoogle Scholar
  80. 80.
    Ongkasuwan C, Taylor JE, Tang CK, Prempree T (1982) Angiosarcomas of the uterus and ovary. Clinicopathologic report. Cancer 49: 1469PubMedCrossRefGoogle Scholar
  81. 81.
    Osborne BM, Robboy SJ (1983) Lymphomas or leukemia presenting as ovarian tumors. An analysis of 42 cases. Cancer 52: 1933PubMedCrossRefGoogle Scholar
  82. 82.
    Paladugu RR, Bearman RM, Rappaport H (1980) Malignant lymphoma with primary manifestation in the gonad. A clinicopathologic study of 38 patients. Cancer 45: 561PubMedCrossRefGoogle Scholar
  83. 83.
    Prat J (1979) Sarcomas of the ovary. Pathol Res Pract 165: 146Google Scholar
  84. 84.
    Prat J, Scully RE (1981) Cellular fibromas and fibrosarcomas of the ovary. A comparative clinicopathologic analysis of seventeen cases. Cancer 47: 2663PubMedCrossRefGoogle Scholar
  85. 85.
    Prayson RS, Hart WR (1992) Primary smooth muscle tumors of the ovary. A clinicopathologic study of four leiomyomas and two mitotically active leiomyomas. Arch Pathol Lab Med 116: 1068PubMedGoogle Scholar
  86. 86.
    Rappaport H (1966) Tumors of the hematopoietic system. Atlas of tumor pathology, Sect 3, Vol. 8. Washington, D.C., Armed Forces Institute of Pathology.Google Scholar
  87. 87.
    Raggio M, Kaplan AL, Harberg JF (1983) Recurrent ovarian fibromas with basal cell nevus syndrome (Gorlin syndrome). Obstet Gynecol 61: 95SPubMedGoogle Scholar
  88. 88.
    Rice M, Pearson B, Treadwell WB (1943) Malignant lymphangioma of the ovary. Am J Obstet Gynecol 45: 884Google Scholar
  89. 89.
    Rotmensch J, Woodruff JD (1982) Lymphoma of the ovary. Report of twenty new cases and update of previous series. Am J Obstet Gynecol 143: 870PubMedGoogle Scholar
  90. 90.
    Sandison AT (1955) Rhabdomyosarcoma of the ovary. J Pathol Bacteriol 70: 433PubMedCrossRefGoogle Scholar
  91. 91.
    Schmeisser HC, Anderson WAD (1938) Ganglioneuroma of the ovary. JAMA 111: 2005CrossRefGoogle Scholar
  92. 92.
    Scully RE (1979) Tumors of the ovary and maldeveloped gonads. Vol 16, 2nd ser. Washington, D.C., Armed Forces Institute of Pathology.Google Scholar
  93. 93.
    Seed PG (1966) Burkitt’s tumour in Britain. J Obstet Gynecol Br Commonw 73: 808CrossRefGoogle Scholar
  94. 94.
    Shaeffer MD, Cancelmo JJ (1939) Cavernous hemangioma of the ovary in a girl twelve years of age. Am J Obstet Gynecol 38: 722Google Scholar
  95. 95.
    Shearer JP (1935) Hemangioma of the ovary. Reported in a child 3½ years of age. Med Ann DC 4: 223Google Scholar
  96. 96.
    Shipton EA, Meares SD (1965) Heterotopic bone formation in the ovary. Aust NZ J Obstet Gynecol 5: 100CrossRefGoogle Scholar
  97. 97.
    Smith FR (1931) Neurofibroma of the ovary associated with Recklinghausen’s disease. Am J Cancer 15: 859Google Scholar
  98. 98.
    Stamm C (1891) Beitrag zur Lehre von Blutgefassge-schwulsten. Thesis. University of Gottingen.Google Scholar
  99. 99.
    Stone GC, Bell DA, Fuller A, Dickersin GR, Scully RE (1986) Malignant Schwannoma of the ovary. Report of a case. Cancer 58: 1575PubMedCrossRefGoogle Scholar
  100. 100.
    Stout AP (1948) Myxoma, tumor of primitive mesenchyme. Ann Surg 127: 706PubMedCrossRefGoogle Scholar
  101. 101.
    Stowe LM, Watt JY (1952) Osteogenic sarcoma of the ovary. Am J Obstet Gynecol 64: 422PubMedGoogle Scholar
  102. 102.
    Talerman A (1967) Hemangiomas of the ovary and the uterine cervix. Obstet Gynecol 30: 108PubMedGoogle Scholar
  103. 103.
    Talerman A, Auerbach WM, Van Meurs AJ (1981) Primary chondrosarcoma of the ovary. Histopathology 5: 319PubMedCrossRefGoogle Scholar
  104. 104.
    Talerman A, Montero JR, Chilcote RR, Okagald T (1985) Diffuse malignant peritoneal mesothelioma in a 13-year-old girl. Am J Surg Pathol 9: 73PubMedCrossRefGoogle Scholar
  105. 105.
    Taxy JB, Battifora H, Oyasu R (1974) Adenomatoid tumors. A light microscopic, histochemical and ultrastructural study. Cancer 34: 306PubMedCrossRefGoogle Scholar
  106. 106.
    Voegt H (1938) Extramedullary plasmacytoma. Virch Arch [Pathol Anat] 302: 497CrossRefGoogle Scholar
  107. 107.
    Warhol MJ, Hunter NJ, Carson JM (1982) An ultrastructural comparison of mesotheliomas and adenocarcinomas of ovary and endometrium. Int J Gynecol Pathol 1: 125PubMedCrossRefGoogle Scholar
  108. 108.
    Willis RA (1967) Pathology of tumours, 4th ed. London, Butterworths.Google Scholar
  109. 109.
    Woodruff JD, Noll Castillo RD, Novak ER (1963) Lymphoma of the ovary. Am J Obstet Gynecol 85: 912PubMedGoogle Scholar
  110. 110.
    Young RH, Scully RE (1983) Ovarian tumors of probable wolffian origin. A report of 11 cases. Am J Surg Pathol 7: 125PubMedCrossRefGoogle Scholar
  111. 111.
    Young RH, Scully RE (1984) Fibromatosis and massive edema of the ovary, possibly related entities. A report of 14 cases of fibromatosis and 11 cases of massive edema. Int J Gynecol Pathol 3: 153PubMedCrossRefGoogle Scholar
  112. 112.
    Young RH, Scully RE (1985) Ovarian metastases from cancer of the lung. Problems in interpretation. A report of seven cases. Gynecol Oncol 21: 337PubMedCrossRefGoogle Scholar
  113. 113.
    Young RH, Dickersin GR, Scully RE (1987) Small cell carcinoma of the ovary. An analysis of 75 cases of a distinctive ovarian tumor commonly associated with hypercalcemia. (Abstract) Lab Invest 56: 89AGoogle Scholar
  114. 114.
    Ziegler JL (1977) Treatment results of 54 American patients with Burkitt’s lymphoma are similar to the African experience. N Engl J Med 297: 75PubMedCrossRefGoogle Scholar

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  • Aleksander Talerman

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