Ocular Effects and Clearance of Intravitreal 5-Fluorouracil
Proliferative vitreoretinopathy (PVR) (1) continues to be a major cause of recurrent retinal detachments following scleral buckling procedures. Improved pars plana vitrectomy techniques (2) combined with intravitreal tamponades (3, 4) now permit successful reattachment of many of these cases. Recent studies have found that 5-Fluorouracil (5-FU) markedly reduces the proliferative activity of the fibroblasts and retinal pigment epithelial cells which result in recurrent retinal detachment.
KeywordsToxicity HPLC Retina Half Life Diethyl
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