Information Sources for Genomics

  • Eugene V. Koonin
  • Michael Y. Galperin


The ultimate goal of genome analysis is understanding the biology of each particular organism in both functional and evolutionary terms, which requires combining disparate data from a variety of sources. Reliable information resources, compiling data on sequenced genomes and linking it to the wealth of associated functional data, are indispensable for comparative genomics. The amount of genome-related information stored in public databases and freely available to anyone with an Internet access is enormous. It has been our experience, however, that many researchers who should benefit the most from this information are not comfortable navigating these databases, let alone assessing the reliability of the data. This chapter is an attempt to bring the genomic databases closer to their principal users, molecular biologists and biochemists.


Protein Data Bank European Bioinformatics Institute Enzyme Commission Number Functional Assignment European Molecular Biology Laboratory 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Further Reading

  1. 1.
    Nucleic Acids Research, 1998–2002, January 1st issuesGoogle Scholar
  2. 2.
    Computer Methods for Macromolecular Sequence Analysis. 1996. Doolittle R.F., ed. (Methods in Enzymology, vol. 266). Academic Press, San Diego.Google Scholar
  3. 3.
    Analysis of Amino Acid Sequences. 2000. Bork P., ed. (Advances in Protein Chemistry, vol. 54). Academic Press, San Diego. The following articles are relevant for this chapter: Apweiler R. Protein sequence databases, pp. 31–71 Bateman A., Birney E. Searching databases to find protein domain organization, pp. 137–157 Kanehisa M. Pathway databases and higher order function, pp. 381–408.Google Scholar
  4. 4.
    Bioinformatics: Databases and Systems. 1999. Letovsky S.L., ed. Kluwer Academic Publishers, Boston.Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2003

Authors and Affiliations

  • Eugene V. Koonin
    • 1
  • Michael Y. Galperin
    • 1
  1. 1.National Center for Biotechnology Information, National Library of MedicineNational Institutes of HealthUSA

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