Evolutionary Concept in Genetics and Genomics

  • Eugene V. Koonin
  • Michael Y. Galperin


In times past, gathering information on a potential partner in marriage or business routinely started with the simplest question “What family does he or she come from?” Affiliation with a certain family immediately provided a starting point for further inquiries, a general idea of what might be expected from a certain individual. Of course, families are never uniform, and classic literature from Homer to Shakespeare to Tolstoy provides ample illustrations that any expectation based solely on family history should be taken with a grain of salt. Nevertheless, absent other clues to the character of the subject in question, an educated guess could be made based on the family structure and the individual’s position within that structure.


Horizontal Gene Transfer Evolutionary Concept Lateral Gene Transfer Phosphoglycerate Mutase Phyletic Pattern 
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Further Reading

  1. 1.
    Darwin C. 1859. The Origin of Species. Murray, Londonx.Google Scholar
  2. 2.
    Kimura M. 1983. The Neutral Theory of Molecular Evolution. Cambridge University Press, Cambridge, UK.CrossRefGoogle Scholar
  3. 3.
    Ohno S. 1970. Evolution by Gene Duplication. Springer, New York.Google Scholar
  4. 4.
    Graur D, Li W-H. 2000. Fundamentals of Molecular Evolution. Sinauer Associates, Sunderland, MA.Google Scholar
  5. 5.
    Doolittle WF. 2000. Uprooting the tree of life. Scientific American 282: 90–95.PubMedCrossRefGoogle Scholar
  6. 6.
    Koonin EV, Aravind L, Kondrashov AS. 2000. The impact of comparative genomics on our understanding of evolution. Cell 101: 573–576.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2003

Authors and Affiliations

  • Eugene V. Koonin
    • 1
  • Michael Y. Galperin
    • 1
  1. 1.National Center for Biotechnology Information, National Library of MedicineNational Institutes of HealthUSA

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