Venous Thrombotic Disease

  • Pearse Morris


Cerebral venous thrombosis is associated with a variety of systemic illnesses, sepsis, pregnancy, coagulation defects, and autoimmune states. Deficiencies of antithrombin III, protein C, protein S, and factor V Leiden, or an increase in anticardiolipin A antibodies may be identified in patients with this disorder, but a precise pathogenesis may not be identifiable in 25% to 35% of patients.1 The disease is frequently overlooked clinically and on CT imaging, in part due to a low clinical suspicion of the disease stemming from its ability to simulate the clinical appearance of benign intracranial hypertension, neoplasms, encephalitis, or cerebrovascular accident.2 However, MRI with contrast, MR venography, and CT angiography all enhance reader sensitivity to this disease. The prognosis of the disease is unpredictable and variable. Mortality rates up to 33% can be reported depending on the underlying disease state and the presence or absence of hemorrhagic venous infarcts.3


Sinus Thrombosis Superior Sagittal Sinus Cerebral Venous Thrombosis Transverse Sinus Dural Sinus 
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© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Pearse Morris
    • 1
  1. 1.School of MedicineWake Forest UniversityWinston-SalemUSA

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