Macroanatomical Findings in Post-Mortem Brain Tissue

  • G. D. Pearlson
Part of the Neurobiological Foundation of Aberrant Behaviors book series (NFAB, volume 4)


In this chapter, I will discuss gross pathologic changes associated with major affective disorders, specifically brain weight and both overall and regional volume changes, including a number of microscopic studies that assessed volumes of defined structures.

Any attempt to review and summarize existing macroanatomical findings in post-mortem brain tissue in affective disorders immediately confronts several difficulties. The total number of studies on the neurohistology of mood disorders is remarkably small, even in comparison to other neuropsychiatric disorders such as schizophrenia.


Bipolar Disorder Affective Disorder Mood Disorder White Matter Lesion White Matter Hyperintensities 


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