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Methodological Issues in the Analysis of Quality of Life Data in Clinical Trials: Illustrations from the National Surgical Adjuvant Breast and Bowel Project (NSABP) Breast Cancer Prevention Trial

  • Stephanie Land
  • Samuel Wieand
  • Richard Day
  • Tom Ten Have
  • Joseph P. Costantino
  • Wei Lang
  • Patricia A. Ganz

Abstract

We present two Quality of Life (QOL) endpoints collected in conjunction with the recently completed Breast Cancer Prevention Trial (BCPT) performed by the National Surgical Adjuvant Breast and Bowel Project. The analyses of these endpoints (depression and hot flashes) indicate the importance of randomization and give some insight about the impact of missing data in a large randomized trial.

Keywords

Depressive Symptom National Surgical Adjuvant Breast Naive Model Breast Cancer Prevention Trial Missing Form 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 2002

Authors and Affiliations

  • Stephanie Land
    • 1
    • 2
    • 3
  • Samuel Wieand
    • 1
    • 2
    • 3
  • Richard Day
    • 1
    • 2
    • 3
  • Tom Ten Have
    • 4
  • Joseph P. Costantino
    • 1
    • 2
    • 3
  • Wei Lang
    • 5
  • Patricia A. Ganz
    • 6
    • 7
    • 8
  1. 1.University of PittsburghUSA
  2. 2.The National Surgical Adjuvant BreastUSA
  3. 3.Bowel ProjectUSA
  4. 4.University of Pennsylvania School of MedicineUSA
  5. 5.Wake Forest University School of MedicineUSA
  6. 6.UCLA Schools of MedicineUSA
  7. 7.Public HealthUSA
  8. 8.The Jonsson Comprehensive Cancer CenterUSA

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