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Latent Class Models to Describe Changes Over Time: A Case Study

  • Hans C. van Houwelingen

Abstract

By means of a case study we describe the statistical analysis of repeated measures as they may be found in a typical quality-of-life trial that studies the effect of some intervention on quality-of-life. We will show that latent class models are a very useful to tool to discover patterns in the follow-up data. Once the patterns have been found, data-driven summary statistics can be defined that are more useful than simple pre-defined measures of response.

Keywords

Pain Score Principal Curve Multivariate Normal Distribution Latent Class Model Intermediate Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 2002

Authors and Affiliations

  • Hans C. van Houwelingen
    • 1
  1. 1.Leiden University Medical CenterNetherlands

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