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Endothelin G Protein-Coupled Receptors

  • Gastone G. Nussdorfer
  • Gian Paolo Rossi
Part of the Endocrine Updates book series (ENDO, volume 17)

Abstract

Endothelins (ETs) are a family of endogenous peptides, mainly secreted by endothelial cells, which exert a potent vasoconstrictor and pressor activity, acting through two classes of G protein-coupled receptors, called ETa and ETb. ETs were originally isolated from porcine aortic endothelium [1], but subsequent investigations revealed that these peptides are synthesized and their receptors are expressed in a great variety of tissues and organs, where they play important physiological and pathophysiological roles [2–6]. At present, ETs are known to regulate the cardiovascular system and blood pressure (BP), kidney excretion, pulmonary function, endocrine-gland secretion, digestive functions, and the development of tissues derived from embryonic neural-crest lineage and of the central and peripheral nervous systems. The ability of all these tissues to synthesize ETs and the fact that the blood concentrations of ETs are below those able to evoke sizeable biological effects led to the contention that these peptides almost exclusively act through autocrine-paracrine mechanisms.

Keywords

Granulosa Cell Zona Glomerulosa Coronary Artery Smooth Muscle Cell Human Coronary Artery Smooth Muscle Adrenal Zona Glomerulosa Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Gastone G. Nussdorfer
    • 1
  • Gian Paolo Rossi
    • 2
  1. 1.Departments of Human Anatomy and PhysiologyUniversity of PaduaPaduaItaly
  2. 2.Clinical and Experimental Medicine, School of MedicineUniversity of PaduaPaduaItaly

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