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Gonadotropin and TSH Receptors

  • Nicolas de Roux
  • Beate Doeker
  • Edwin Milgrom
Part of the Endocrine Updates book series (ENDO, volume 17)

Abstract

Luteinizing hormone (LH), follicule-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH) are glycoproteins synthesized by the pituitary. In females, LH stimulates androgen synthesis by ovarian thecal cells and triggers ovulation. In males, LH stimulates testosterone production by Leydig cells. In the ovary, FSH stimulates granulosa cell estrogen production from androgens synthesized in thecal cells. In males, FSH regulates Sertoli cell function in the testis. TSH stimulates thyroid hormone synthesis by thyroid follicular cells. All three are heterodimeric hormones with a common α subunit and a specific β subunit. Chorionic gonadotropin (CG) is the fourth member of this family found only in human (hCG) and equine (eCG) species where it is synthesized by the placenta. It is also a heterodimeric hormone composed of the common α subunit and a specific β subunit highly homologous to the β LH subunit.

Keywords

Leydig Cell Congenital Hypothyroidism Luteinizing Hormone Receptor Thyrotropin Receptor Adenylate Cyclase Stimulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Nicolas de Roux
    • 1
  • Beate Doeker
    • 1
  • Edwin Milgrom
    • 1
  1. 1.INSERM Unit135, Laboratoire d’Hormonologie et de Biologie MoleculaireHôpital BicêtreLe Kremlin BicêtreFrance

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