Ovarian Cancer pp 213-228 | Cite as

Telomerase and Malignant Transformation

  • Jiamei Yu
  • Louis Dubeau
Part of the Cancer Treatment and Research book series (CTAR, volume 107)


Recent progress in our understanding of the role of telomeres and telomerase in cell proliferation, malignant transformation, and genomic stability has opened new possibilities for cancer diagnosis, detection, and treatment. Novel approaches based on this knowledge are being investigated in different laboratories and are likely to have a significant impact on cancer management protocols in the future. This chapter gives an overview of our current knowledge of the function of telomeres and of the mechanisms responsible for their maintenance, followed by comments on potential applications of this knowledge in clinical medicine.


Telomere Length hTERT Expression Telomere Elongation 


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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Jiamei Yu
    • 1
  • Louis Dubeau
    • 1
  1. 1.Department of Pathology, Keck School of Medicine of the University of Southern CaliforniaUSC/Norris Comprehensive Cancer CenterLos AngelesUSA

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