A pulsatile pattern of GnRH release is a requirement for the maintenance of normal reproductive function (see Levine et al., 1995; Levine, 1999; Lopez et al., 1998; Stojilkovic et al., 1994; Terasawa, 1998 for reviews). GnRH pulsatility occurs in all vertebrate species studied to date. Each pulse of GnRH that is released into the portal circulation stimulates the release of the gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn are released in discrete pulses from the anterior pituitary gland into the general circulation. When an organism is exposed to a continuous pattern of GnRH, reproductive function is disrupted, while a pulsatile pattern of GnRH infusion maintains normal reproductive function (Belchetz et al., 1978; Figure 8).
KeywordsLuteinizing Hormone GnRH Neuron Luteinizing Hormone Release GnRH Release Medial Basal Hypothalamus
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