The physiology, anatomy, and molecular biology of the nRH system in humans are quite similar to those of all other mammals studi d to date. This is not surprising, as the GnRH molecule and the GnRH neurosecretory system as the whole are highly conserved across evolution. Therefore, the experimental studies on humans can be used together with bas c research from animal models to develop clinical therapies for mitigating GnRH deficiencies and in treating infertility and disorders of puberty. In this chapter, the properties of human GnRH-1 neurons will be presented, and clinical disorders and therapies will be discussed.
KeywordsPrecocious Puberty GnRH Receptor GnRH Neuron Pulsatile GnRH GnRH mRNA
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