The Mechanisms of Morphine Dependence and It’s Withdrawal Syndrome: Study in Mutant Mice
The catecholaminergic systems appear to mediate some of physical dependence of opiates.1 For example, Clonidine, a drug that decreases noradrenergic activity, prevents behavior induced by morphine withdrawal.2 An increase in the noradrenergic neuron firing rate in the locus coeruleus (LC) 3 and an increase in the turnover of noradrenaline (NA) have been reported during naloxone-precipitated morphine withdrawal.4
KeywordsTyrosine Hydroxylase Locus Coeruleus Withdrawal Syndrome Morphine Withdrawal CREB Binding Protein
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