Molecular Mechanism of the Regulation of the Biological Clock in Mammals

  • Hitoshi Okamura
  • Kazuhiro Yagita
  • Shun Yamaguchi
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)


Most organisms on earth produce a variety of behavioral or physiological rhythms with periods that are close to 24 hours. Such “circadian” rhythms are genetically determined at least in cyanobacteria, Arabidopsis, Neurospora, Drosophila and rodents, and recent progress of the molecular dissection opens up the clock genes and their timekeeping mechanisms. A recent genetic screening of human disease of Utah’s group verified the clock generation mechanism is common even in human (Toh et al., 2001). Here we describe our data related to the molecular mechanism of the clock gene in mammals.


Circadian Clock Clock Gene Suprachiasmatic Nucleus Biological Clock Peripheral Clock 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Hitoshi Okamura
    • 1
  • Kazuhiro Yagita
  • Shun Yamaguchi
    • 1
  1. 1.Division of Molecular Brain Science, Department of Brain SciencesKobe University Graduate School of MedicineKobeJapan

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