Part of the
Advances in Behavioral Biology
book series (ABBI, volume 53)
Effects of Histaminergic Drugs on Dopaminergic and Cholinergic Brain Activity in the Rat
Relevance for mechanisms of memory and reward
Neuronal histamine in the brain is provided exclusively by a group of neurons located in the tuberomammillary nucleus (TM) of the posterior hypothalamus. The histaminergic fibers originating from this area are highly divergent and project to almost all brain regions, where they exert their effects through H1, H2, and H3 receptors.1, 2 Brain histamine seems to be involved in a number of functions, including arousal, sleep/wake cycle, feeding, drinking, aggression, learning, memory, reinforcement, and functional recovery after brain damage.3, 4 Here, neurochemical studies will be reviewed where the effects of H1 antagonists or histamine where studied on extracellular dopamine (DA) and acetylcholine (ACh) in the rat brain. The rationale for these experiments was obtained from behavioral work showing pronounced effects of histaminergic manipulations on learning, memory, and reinforcement. These studies will shortly also be addressed.
KeywordsConditioned Place Preference Extracellular Dopamine Histaminergic Neuron Histamine Injection Brain Histamine
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