Noradrenergic Control of Long-Term Memory Consolidation
Memory formation involves dynamic interactions among many brain structures and their linking pathways. Long-term memory requires de novo protein synthesis and gene expression, and is mediated by some intracellular signaling pathways. The noradrenaline (NA) system in the CNS is known to mediate a wide variety of neurological and psychological functions, such as cognition, attention, and memory formation. Clinical investigations have implicated alterations in the NA system in the pathological states of neuropsychiatric diseases. Tyrosine hydroxylase (TH) is the first and rate-limiting enzyme of catecholamine biosynthesis. The regulatory mechanism of the TH reaction is considered to play a key role in controlling the catecholaminergic actions. In this report, we describe a behavioral analysis of mice heterozygous for the mutation in the TH gene. We provide genetic evidence for an essential role of the NA system in the consolidation process of long-term memory of certain learning paradigms.1
KeywordsConditioned Stimulus Tyrosine Hydroxylase Mutant Mouse Unconditioned Stimulus Memory Consolidation
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