The Role of the Central Catecholamine System in the Organization of Neuronal and Neurohumoral Responses to Various Stressful Stimuli

  • Miklós Palkovits
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)


Neuroanatomically, the routes of neurogenic stressors are constituted by neuronal pathways for stressful signals to brain centers (ascending pathways), and neuronal pathways carrying stress response signals to the periphery (descending pathways). They may consist of short loop reflexes (spinal and supraspinal) or long loop circuits (ascending neuronal pathways — higher centers [hypothalamus, limbic system. neocortex] — descending neuronal pathways with outputs to the periphery). Both are involved in stress responses with or without the participation of central catecholaminergic (CA) neurons. Different stressors may act on different central CA neurons, and vice versa, different CA neurons are diversely involved in stress responses. Their anatomical organization, however, is similar: CA neurons participate both in the ascending and descending stress pathways.


Neuronal Pathway Stria Terminalis Parabrachial Nucleus Hypothalamic Paraventricular Nucleus Preganglionic Neuron 
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  1. 1.
    R. Burstein, K.D. Cliffer, and G.J.J. Giesler, Direct somatosensory projections from the spinal cord to the hypothalamus and telencephalon, J. Neurosci. 7, 4159–4164 (1987).PubMedGoogle Scholar
  2. 2.
    D. Lima, and A. Coimbra, Neurons in the substantia gelatinosa rolandi (lamina H.) project to the caudal ventrolateral reticular formation of the medulla oblongata in the rat, Neurosci. Lett. 132, 16–18 (1991).PubMedCrossRefGoogle Scholar
  3. 3.
    D. Menétrey, and A.I. Basbaum, Spinal and trigeminal projections to the nucleus of the solitary tract: A possible substrate for somatovisceral and viscerovisceral reflex activation, J. Comp. Neurol. 255, 439–450 (1987).PubMedCrossRefGoogle Scholar
  4. 4.
    K. Pacak, M. Palkovits, I.J. Kopin, and D.S. Goldstein, Stress-induced norepinephrine release in the hypothalamic paraventricular nucleus and pituitary-adrenocortical and sympathoadrenal activity. In vivo microdialysis studies, Front. Neuroendocrinal. 16, 89–150 (1995).CrossRefGoogle Scholar
  5. 5.
    K. Pacak, M. Palkovits, G. Yadid, R. Kvetnansky, I.J. Kopin, and D.S. Goldstein, Heterogeneous neurochemical responses to different stressors: A test of Selye’s doctrine of nonspecificity, Amer. J. Physiol. 275, R1247–R1255 (1998).Google Scholar
  6. 6.
    M. Palkovits, Interconnections between the neuroendocrine hypothalamus and the central autonomic system, Front. Neuroendocrinol. 20, 270–295 (1999).PubMedCrossRefGoogle Scholar
  7. 7.
    M. Palkovits, J.S. Baffi, and S. Dvori, Neuronal organization of stress response: Pain-induced c-fos expression in brain stem catecholaminergic cell groups, Ann. N.Y. Acad. Sci. 771, 313–326 (1995).PubMedCrossRefGoogle Scholar
  8. 8.
    M. Palkovits, J.S. Baffi, and K. Pacak, The role of ascending neuronal pathways in stress-induced release of norepinephrine in the hypothalamic paraventricular nucleus of rats, J. Neuroendocrinol. 11, 529–539 (1999).PubMedCrossRefGoogle Scholar
  9. 9.
    M. Palkovits, G.B. Makara, Cs. Léránth, and H. Van Cuc, Intrahypothalamic terminals of stress conducting fibers, Brain Res. 190, 399–407 (1980).PubMedCrossRefGoogle Scholar
  10. 10.
    Zs. Títh, K. Gallatz, M. Fodor, M. Palkovits, Decussations of the descending paraventricular pathways to the brainstem and spinal cord autonomic centers, J. Comp. Neurol. 414, 255–266 (1999).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Miklós Palkovits
    • 1
  1. 1.Department of AnatomySemmelweis UniversityBudapestHungary

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