Differential Gene Expression of Tyrosine Hydroxylase in Rats Exposed Long-Term to Various Stressors
Activity of the sympathetic-adrenomedullary system (SAS) in rats exposed to heterotypic novel stressors after prior chronic stress exposure is poorly understood. A potentiation of SAS activity evaluated by plasma catecholamine levels in chronically stressed rats exposed to novel stressors has been reported (Dronjak et al., 2001). The exaggerated effect of novel stressors is an interesting phenomenon, but its mechanism at the level of adrenomedullary gene expression of catecholamine biosynthetic enzymes is not known.
KeywordsTyrosine Hydroxylase Adrenal Medulla Immobilization Stress Plasma Catecholamine Level Tyrosine Hydroxylase mRNA
Unable to display preview. Download preview PDF.
- Dronjak, S., Ondriska, M., Svetlovska, D., Jezova, D. and Kvetnansky, R., 2001, Effect of novel stressors on plasma catecholamine levels in rats exposed to long-term cold, in: Stress: Neural, Endocrine and Molecular Studies, R. McCarty, et al., eds. Gordon and Breach, New York (in press).Google Scholar
- Kvetnansky, R., Jelokova, J., Rusnak, M., Dronjak, S., Serova, L., Nankova, B.B. and Sabban, E.L., 2001, Novel stressors exaggerate the tyrosine hydroxylase gene expression in the adrenal medulla of rats exposed to long-term cold stress, in: Stress: Neural, Endocrine and Molecular Studies. R. McCarty, et al., eds. Gordon and Breach, New York (in press).Google Scholar
- Kvetnansky, R. and Sabban, E.L., 1993, Stress-induced changes in tyrosine hydroxylase and other catecholamine biosynthetic enzymes, in: Tyrosine Hydroxylase: From Discovery To Cloning. M. Naoi, and S.H. Parvez, eds., Utrecht, VSP Press, pp. 253–281.Google Scholar
- Nankova, B.B., Kvetnansky, R., McMahon, A., Viskupic, E., Hiremagalur, B., Frankle, W.G., Fukuhara, K., Kopin, I.J. and Sabban, E.L., 1994, Induction of tyrosine hydroxylase gene expression by a non-neuronal non-pituitary mediated mechanism in immobilization stress, Proc. Natl. Acad. Sci., USA, 91, 5937–5941.PubMedCrossRefGoogle Scholar