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The Role of Angiotensin II AT1 Receptors in the Sympathoadrenal Response to Stress

  • Ines Armando
  • Andrea Carranza
  • Yasuaki Nishimura
  • Kwang Lae Hoe
  • Marta Barontini
  • Juan M. Saavedra
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)

Abstract

Angiotensin II (Ang II) is a hormone and brain neuropeptide implicated in the response of the hypothalamic-pituitary-adrenal axis to stress (Saavedra, 1992). Stress increases circulating Ang II (Xang et al., 1993) and the expression of Ang II receptors in brain areas such as the hypothalamic paraventricular nucleus (PVN) is crucial for central control of the stress reaction (Castrén and Saavedra, 1988). Ang II stimulates CRH formation in the PVN during stress (Sumitomo et al., 1991; Aguilera et al., 1995) and this results in increased ACTH and adrenal corticoid release. Ang II has direct effects on adrenal function, stimulating aldosterone secretion from the zona glomerulosa and catecholamine release from the medulla (Aguilera, 1993; Livett et al., 1990). Ang II stimulates vasopressin (AVP) formation and release in the PVN (Saavedra, 1992). Released from the median eminence, AVP participates with CRH and enhances ACTH production (Antoni, 1993).

Keywords

Tyrosine Hydroxylase Zona Glomerulosa Hypothalamic Paraventricular Nucleus Isolation Stress Sympathoadrenal Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Ines Armando
    • 1
    • 2
  • Andrea Carranza
    • 2
  • Yasuaki Nishimura
    • 1
  • Kwang Lae Hoe
    • 1
  • Marta Barontini
    • 2
  • Juan M. Saavedra
    • 1
  1. 1.Section on PharmacologyNational Institute of Mental Health, NIHBethesdaUSA
  2. 2.Centro de Investigaciones EndocrinologicasCONICETBuenos AiresArgentina

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