The Role of Angiotensin II AT1 Receptors in the Sympathoadrenal Response to Stress
Angiotensin II (Ang II) is a hormone and brain neuropeptide implicated in the response of the hypothalamic-pituitary-adrenal axis to stress (Saavedra, 1992). Stress increases circulating Ang II (Xang et al., 1993) and the expression of Ang II receptors in brain areas such as the hypothalamic paraventricular nucleus (PVN) is crucial for central control of the stress reaction (Castrén and Saavedra, 1988). Ang II stimulates CRH formation in the PVN during stress (Sumitomo et al., 1991; Aguilera et al., 1995) and this results in increased ACTH and adrenal corticoid release. Ang II has direct effects on adrenal function, stimulating aldosterone secretion from the zona glomerulosa and catecholamine release from the medulla (Aguilera, 1993; Livett et al., 1990). Ang II stimulates vasopressin (AVP) formation and release in the PVN (Saavedra, 1992). Released from the median eminence, AVP participates with CRH and enhances ACTH production (Antoni, 1993).
KeywordsTyrosine Hydroxylase Zona Glomerulosa Hypothalamic Paraventricular Nucleus Isolation Stress Sympathoadrenal Response
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