Differential Regulation of Myocardial Cell Apoptosis by α- and β-Adrenergic Pathways
The apoptosis of cardiac myocytes may play a role in the development of heart failure.1–3 Norepinephrine is one of factors activated in heart failure4 and can induce myocardial cell apoptosis in culture.5 However, it is unknown if α- and β-adrenergic pathways coordinately or differentially regulate apoptosis and if this apoptotic pathway utilizes common or cell type-specific apoptotic signals.
KeywordsCardiac Myocytes Brain Natriuretic Peptide Atrial Natriuretic Peptide Adrenergic Pathway PCI2 Cell
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- 4.GS. Francis, JN. Chon, G. Johnson, TS. Rector, S. Goldman, A. Simon, Plasma norepinephrine, plasma renin activity, and congestive heart failure. Relations to survival and the effects of therapy in V-HeFT II. The V-HeFT VA Cooperative Studies Group, Circulation. 87 (6 Suppl),VI40-VI48 (1993).Google Scholar
- 9.K. Hasegawa, H. Fujiwara, H. Itoh, K. Nakao, T. Fujiwara, H. Imura, C. Kawai, Light and electron microscopic localization of brain natriuretic peptide in relation to atrial natriuretic peptide in porcine atrium-Immunohistochemical study using specific monoclonal antibodies, Circulation. 84, 1203–1209 (1991).PubMedCrossRefGoogle Scholar