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Regulation of Cell Death by the Bcl-2 Family of Proteins

  • Yoshihide Tsujimoto
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)

Abstract

One of the promising approaches for the treatment or prevention of neurodegenerative diseases, including Parkinson’s disease, is to investigate the molecular basis of neurodegeneration or neuronal death and elucidate possible therapeutic molecular targets. The Bcl-2 family of proteins is a major cell death regulator and is implicated in determining the survival or death of neurons under physiological as well as pathological conditions. I will provide an overview of the functions of this family of proteins and their targets, and will discuss a possible molecular approach for the prevention of neurodegenerative diseases.

Keywords

Spinal Muscular Atrophy Necrotic Cell Death Spinal Muscular Atrophy Patient Necrotic Death Therapeutic Molecular Target 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Yoshihide Tsujimoto
    • 1
  1. 1.Lab. Molecular GeneticsOsaka University Graduate School of MedicineSuita, OsakaJapan

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