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Adrenergic Control of Microglia

  • Junya Tanaka
  • Kohji Mori
  • Emi Ozaki
  • Yoshihiro Konishi
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)

Abstract

Microglial cells, which are responsible for immunological surveillance of the brain, may intimately interact with neurons, since they become activated at the earliest phase of neuropathological processes in response to even minor damage of neurons.1 Some diffusible factors from neurons may be important in the rapid functional changes in microglial cells, because most microglial cells are normally surrounded by astrocytes.2 Among the diffusible factors, neurotransmitters such as norepinephrine (NE) are possible candidates responsible for regulating the interactions between neurons and microglial cells. As has been suggested on the basis of electron microscopic study, noradrenergic synapses seem designed to release NE into the extracellular fluid so that they cannot be confined to the vicinity of the synaptic cleft. Microglial cells are known to respond to adrenergic agonists.3 Yet, the expression of adrenergic receptors (AR) has not been identified. Therefore, we first aimed to reveal what types of ARs were expressed in cultured rat microglial cells by RT-PCR in the present study.

Keywords

Electron Spin Resonance Microglial Cell Adrenergic Receptor Synaptic Cleft Adrenergic Agonist 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    G.W. Kreutzberg, Microglia: a sensor for pathological events in the CNS, Trends Neurosci. 19 (1996) 312–318.PubMedCrossRefGoogle Scholar
  2. 2.
    K. Blinzinger, G. Kreutzberg, Displacement of synaptic terminals from regenerating motoneurons by microglial cells, Z. Zellforsch. 85 (1968) 145–157.PubMedCrossRefGoogle Scholar
  3. 3.
    H. Fujita, J. Tanaka, N. Maeda, et al., Adrenergic agonists suppress the proliferation of microglia through β2-adrenergic receptor, Neurosci. Lett. 242 (1998) 37–40.PubMedCrossRefGoogle Scholar
  4. 4.
    K. Mori, E. Ozaki, B. Zhang, et al., Effects of norepinephrine on rat cultured microglial cells that express al, α2, β1, and β2 adrenergic receptors. (update)Google Scholar
  5. 5.
    H. Sugishita, Y. Kuwabara, K. Toku, et al., L-Serine regulates the activities of microglial cells that express very low level of 3-phosphoglycerate dehydrogenase, an enzyme for L serine biosynthesis, J. Neurosci. Res. 64 (2001) 392–401.PubMedCrossRefGoogle Scholar
  6. 6.
    J. Tanaka, K. Toku, S. Matsuda, et al., Induction of resting microglia in culture medium devoid of glycine and serine, Glia 24 (1998) 198–215.PubMedCrossRefGoogle Scholar
  7. 7.
    B, Zhang, L. Yang, Y. Konishi, et al., Suppressive effects of phosphodiesterase type IV inhibitors on rat cultured microglial cells: Comparison with other types of cAMP-elevating agents. (update)Google Scholar
  8. 8.
    L. Yang, J. Tanaka, B. Zhang, et al., Astrocytes modulate nitric oxide production by microglial cells through secretion of serine and glycine, Biochem. Biophys. Res. Comm. 251 (1998) 277–282.PubMedCrossRefGoogle Scholar
  9. 9.
    L. Yang, B. Zhang, K. Toku, et al., Improvement of the viability of cultured rat neurons by the non- essential amino acids L-serine and glycine that upregulates expression of the anti-apoptotic gene product Bcl-w, Neurosci. Lett. 295 (2000) 97–100.PubMedCrossRefGoogle Scholar
  10. 10.
    B. Kalyanaraman, C.C. Felix, R.C. Sealy, Electron spin resonance spin stabilization of semiquinones produced during oxidation of epinephrine and its analogues, J. Biol. Chem. 259 (1984) 354–358.PubMedGoogle Scholar
  11. 11.
    K. Toku, J. Tanaka, H. Yano, et al., Microglial cells prevent nitric oxide induced neuronal apoptosis in vitro, J. Neurosci. Res. 53 (1998) 415–425.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Junya Tanaka
    • 1
  • Kohji Mori
    • 1
  • Emi Ozaki
    • 1
  • Yoshihiro Konishi
    • 1
  1. 1.School of Medicine, Department of PhysiologyEhime UniversityShigenobu, EhimeJapan

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