Mechanisms Underlying Neuronal Death Induced by Activated Microglia
Microglia are considered to usually support the survival of neurons. However, in some pathological circumstances, microglia are activated and believed to kill neurons by producing neurotoxic and pro-inflammatory molecules such as nitric oxide, reactive oxygen intermediates and tumor necrosis factor-a. In Parkinson’s disease, an activation of microglia has an essentially important pathogenic implication, because the substantia nigra has a high density of microglia. In fact, activated microglia have been shown to induce degeneration of dopaminergic neurons both in vitro1 and in vivo studies2. Despite the clinical importance, the precise intracellular mechanism for neuronal death triggered by activated microglia is currently unknown.
KeywordsNeuronal Death Reactive Oxygen Intermediate Lysosomal Storage Disease Neuronal PC12 Cell Pathological Circumstance
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