Dopaminergic Regulation of Synaptic Plasticity of Striatal Cholinergic Interneurons
Part of the
Advances in Behavioral Biology
book series (ABBI, volume 53)
Striatal cholinergic interneurons have been implicated in associative learning.1 In behaving monkeys, the tonically active cholinergic interneurons (TANs) acquire dopamine (DA)-dependent conditioned responses during sensorimotor learning.2,3 The conditioned stimulus leads to a transient suppression in the ongoing tonic activity of TANs, which is often preceded by spike firing. However, the underlying cellular mechanism has not been elucidated. We recently found that tetanic stimulation of cortico/thalamostriatal fibers induces simultaneous long-term potentiation (LTP) of excitatory postsynaptic potential (EPSP) and long-term decrease in the failure rate of disynaptically mediated GABAergic inhibitory postsynaptic potential (IPSP) in the cholinergic interneurons of the mouse studied in vitro.4 This potentiation of EPSPs required a rise in postsynaptic Ca2+, possibly through voltage-dependent Ca2+ channels and Ca2+-permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. Moreover, activation of DA D1-like, but not D2-like receptors, was a prerequisite for the LTP of EPSPs. We propose that the dual mechanisms act cooperatively to produce the conditioned pause responses of TANs, which serve to coordinate striatal global activity.
KeywordsDepression Dopamine Serotonin NMDA Catecholamine
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