In Vivo and in Vitro Functions of Two Types of Mao
Monoamine oxidase (MAO) A and B have selective substrate and inhibitor specificity. MAO A and B knock-out mice exhibit distinct neurotransmitter metabolism and behavior, suggesting that these two isoenzymes have distinct functions in vivo. These two isoenzymes are coded by different cDNAs with 70% amino acid identity. Interestingly, Isoleucine 335 in MAO A and the corresponding amino acid in MAO B, tyrosine 326, determine the substrate and inhibitor selectivity in vitro.
KeywordsMonoamine Oxidase Mitochondrial Monoamine Oxidase Norrie Disease Liver Monoamine Oxidase Inhibitor Clorgyline
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