Skip to main content

Chromogranins / Current Concept

  • Chapter
Catecholamine Research

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 53))

  • 26 Accesses

Abstract

The large dense core secretory granules of adrenal medulla chromaffin cells synthesize, store and release catecholamines. Upon cell stimulation intragranular stored material is liberated into circulation to activate target organs. In addition to catecholamines, numerous peptides and proteins are present in chromaffin secretory granules and are exocytotically co-secreted with the catecholamines (Aunis, 1997).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aardal, S., Helle, K.B., Elsayed, S., Reed, R.K., and Serck-Hanssen, G., 1993, Vasostatins, comprising the N- terminal domain of chromogranin A, suppress tension in isolated human blood vessel segments. J. Neuro endo crinol. 5: 405–412.

    CAS  Google Scholar 

  • Aunis, D., 1997, Exocytosis in chromaffin cells of the adrenal medulla. Int. Rev. Cytol. 181: 213–320.

    Google Scholar 

  • Cetin, Y., Aunis, D., Bader, M.F., Galindo, E., Jörns, A., Bargsten, G., and Grübe, D., 1993, Chromostatin, a chromogranin A-derived bioactive peptide, is present in human pancreatic insulin (ß) cells. Proc. Natl. Acad. Sci. USA 90: 2360–2364.

    Article  PubMed  CAS  Google Scholar 

  • Chao, C.C., Hu, S. and Peterson, P.K., 1995, Glia, cytokines and neurotoxicity. Critic. Rev. Neurobiol. 9: 189–205.

    CAS  Google Scholar 

  • Ciesielski-Treska, J. and Aunis, D., 2000, Chromogranin A induces a neurotoxic phenotype in brain microglial cells. Adv. Exptl. Med. Biol. 482: 291–298.

    Article  CAS  Google Scholar 

  • Ciesielski-Treska, J., Ulrich, G., Taupenot, L., Chasserot-Golaz, S., Corti, A., Aunis, D., and Bader, M. F., 1998, Chromogranin A induces a neurotoxic phenotype in brain microglial cells. J. Biol. Chem. 273:14339–14346.

    Article  PubMed  CAS  Google Scholar 

  • Ciesielski-Treska, J., Ulrich, G., Chasserot-Golaz, S., Zwiller, J., Revel, M.O., Aunis, D., and Bader, M. F., 2001, Chromogranin A induces a neurotoxic phenotype in brain microglial cells. J. Biol. Chem. 276: 13113–13120.

    Article  PubMed  CAS  Google Scholar 

  • Eiden, L.E., 1987, Is chromogranin a prohormone? Nature (London) 325: 301.

    Article  CAS  Google Scholar 

  • Dillen, L., Miserez, B., Claeys, M., Aunis, D., and De Potter, W., 1993, Posttranslational processing of proenkephalins and chromogranins/secretogranins. Neurochem. Int. 22: 315–352.

    Article  PubMed  CAS  Google Scholar 

  • Fasciotto, B.H., Trauss, C.A., Greeley, G.H., and Cohn, D.V., 1993, Parastatin (porcine chromogranin A347–419), a novel chromogranin A-derived peptide, inhibits parathyroid cell secretion. Endocrinology 133: 461–466.

    Article  PubMed  CAS  Google Scholar 

  • Giulian, D., Haverkamp, L.J., Li, J., Karshin, W.L., Yu, J., Tom, D., Li, X., and Kirkpatrick, J.B., 1995, Senile plaques stimulate microglia to release a neurotoxin found in Alzheimer disease. Neurochem. Int. 27: 119–137.

    Article  PubMed  CAS  Google Scholar 

  • Goumon, Y., Lugardon, K., Kieffer, B., Lefèvre, J. F., Van Dorsselaer, A., Aunis, D., and Metz-Boutigue, M.H., 1998, Characterization of antibacterial COOH-terminal proenkephalin-A-derived peptides (PEAP) in infectious fluids. Importance of enkelytin, the antibacterial PEAP209–237 secreted by stimulated chromaffin cells. J. Biol. Chem. 273: 29847–29856.

    Article  PubMed  CAS  Google Scholar 

  • Helle, K.B., and Aunis, D., 2000, Chromogranins : from Fundamental to Clinics, Kluwer Academic/Plenum Publishing, New York.

    Google Scholar 

  • Lugardon, K., Raffher, R., Goumon, Y., Corti, Y., Delmas, A., Bulet, P., Aunis, D., and Metz-Boutigue, M.H., 2000, Antibacterial and antifungal activities of vasostatin-1, the N-terminal fragment of chromogranin A. J. Biol. Chem. 275: 19745–19753.

    Article  Google Scholar 

  • Mahata, S.K., O’Connor, D.T., Mahata, M., Yoo, S.H., Taupenot, L., Wu, H., Gill, B.M., and Parmer, R.J., 1997, Novel autocrine feedback control of catecholamine release. A discrete chromogranin A fragment is a noncompetitive nicotinic cholinergic antagonist. J. Clin. Invest. 100: 1623–1633.

    Article  PubMed  CAS  Google Scholar 

  • Metz-Boutigue, M. H., Garcia-Sablone, P., Hogue-Angeletti, R., and Aunis, D., 1993, Intracellular and extracellular processing of chromogranin A determination of cleavage sites. Eur. J. Biochem. 217: 247–257.

    Article  PubMed  CAS  Google Scholar 

  • Metz-Boutigue, M.H., Goumon, Y., Lugardon, K., Strub, J.M., and Aunis, D., 1998, Antibacterial peptides are present in chromaffin cell secretory granules. Cell. Mol. Neurobiol. 18: 249–266.

    Article  PubMed  CAS  Google Scholar 

  • Munoz, D.G., 1991, Chromogranin A-like immunoreactivity neurites are major constituents of senile plaques. Lab. Invest. 64: 826–832.

    PubMed  CAS  Google Scholar 

  • Simon, J.P., and Aunis, D., 1989, Biochemistry of the chromogranin A protein family. Biochem. J. 262: 1–13.

    PubMed  CAS  Google Scholar 

  • Strub, J.M., Garcia-Sablone, P., Lonning, K., Taupenot, L., Hubert, P., Van Doorsselaer, A., Aunis, D., and Metz-Boutigue, M.H., 1995, Processing of chromogranin B in bovine adrenal medulla : identification of secretolytin, the endogenous C-terminal fragment of residues 614–626 with antibacterial activity. Eur. J. Biochem. 229: 356–368.

    Article  PubMed  CAS  Google Scholar 

  • Strub, J.M., Sorokine, O. , Van Doorsselaer, A., Aunis, D., and Metz-Boutigue, M.H., 1997, Phosphorylation and O-glycosylation of bovine chromogranin A from adrenal medullary chromaffin granules and their relationship with biological activities. J. Biol. Chem. 272: 11928–11936.

    Article  PubMed  CAS  Google Scholar 

  • Tatemoto, K., Efendic, S., Mutt, V., Makk, G., Feistner, G. J., and Barchas, J. D., 1986, Pancreastatin, a novel pancreatic peptide that inhibits insulin secretion. Nature (London) 324: 476–478.

    Article  CAS  Google Scholar 

  • Taupenot, L., Ciesielski-Treska, J., Ulrich, G., Chasserot-Golaz, S., Aunis, D. and Bader, M.F., 1996, Chromogranin A triggers a phenotypic transformation and the generation of NO in brain microglial cells. Neuroscience 72: 377–389.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Springer Science+Business Media New York

About this chapter

Cite this chapter

Aunis, D., Metz-Boutigue, MH. (2002). Chromogranins / Current Concept. In: Nagatsu, T., Nabeshima, T., McCarty, R., Goldstein, D.S. (eds) Catecholamine Research. Advances in Behavioral Biology, vol 53. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3538-3_3

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-3538-3_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-3388-1

  • Online ISBN: 978-1-4757-3538-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics