Catecholamine — Neuropeptide Interactions
It is now well established that neuropeptides act as messenger molecules in the nervous system, and they often coexist with classical transmitters such as noradrenaline (NA), acetylcholine, and amino acids (see 1). In fact, the first example in the mammalian nervous system showed that peripheral sympathetic noradrenergic neurons express the tetradecapeptide somatostatin, a study based on immunohistochemistry using antibodies to the catecholamine synthesizing enzyme dopamine beta-hydroxylase (DBH).2 This was possible thanks to our collaboration with the late Professor Menek Goldstein at New York University School of Medicine, since he isolated all four enzymes in the catecholamine (CA) synthesis pathway and raised antibodies to these enzymes.3 This was the basis for Kjell Fuxe’s and my interaction with Menek over a period of three decades starting in 1969. It is an honour to acknowledge Menek Goldstein’s contributions to our work on CA-peptide interactions.
KeywordsLocus Coeruleus Nephrogenic Diabetes Insipidus Locus Coeruleus Neuron Galanin Receptor Magnocellular Neuron
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