Sympathoadrenal Activity and Cardiovascular Responses during Space Flight

  • Niels Juel Christensen
  • Peter Norsk
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)


Several ground-based simulation studies have been performed during which the gravitational stress has been reduced for shorter or longer periods of time. Simulated microgravity induces an increase in central venous pressure and a decrease in plasma norepinephrine (NE). In one experiment lasting 42 days of head-down tilted bed rest plasma NE did not change. These studies have therefore suggested that sympathoadrenal activity remains- unchanged or may even be reduced during a space mission. This hypothesis has, however, been refuted.1


Plasma Volume Space Flight Muscle Sympathetic Nerve Activity Simulated Microgravity Lower Body Negative Pressure 
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  1. 1.
    P. Norsk, C. Drummer, L. Rocker, F. Strallo, N.J. Christensen, J. Warberg, P. Bie, C. Stadeager, L. B. Johansen, M. Heer, H-C. Gunga and R. Gerzer, Renal and endocrine reponses in humans to isotonic saline infusion during microgravity J. Appl. Physiol. 78, 2253–2259 (1995).PubMedCrossRefGoogle Scholar
  2. 2.
    P. Norsk, N. J. Christensen, P. Bie, A. Gabrielsen, M. Heer, C. Drummer, Unexpected renal responses in space. Lancet 356 1577–1578 (2000).PubMedCrossRefGoogle Scholar
  3. 3.
    N. J. Christensen, The biochemical assessment of sympathoadrenal activity in man. Clinical Autonomic Research 1 167–172(1991).PubMedCrossRefGoogle Scholar
  4. 4.
    N. J. Christensen, J. H. Knudsen, Peripheral catecholaminergic function evaluated by norepinephrine measurements in plasma, extracellular fluid, and lymphocytes, from nerve recordings and cellular responses. Adv. Pharmacol. 42 540–544 (1998).PubMedCrossRefGoogle Scholar
  5. 5.
    C. P. Alfrey, M. M. Udden, C. Leach-Huntoon, T. Driscoll, M. H. Pickett, Control of red blood cell mass in spaceflight. J. Appl. Physiol. 81 98–104 (1996)PubMedGoogle Scholar
  6. 6.
    C Drummer, R. Gerzer, F. Baisch, M. Heer, Body fluid regulation in jn-gravity differs from that on Earth: an overview. Pflügers Arch. 441 (2–3 Suppl) R66–72 (2000).Google Scholar
  7. 7.
    L. C. Senay Jr, Changes in plasma volume and protein content during exposures of working men to various temperatures before and after acclimatization to heat: separation of the roles of cutaneous and skeletal muscle circulation. J. Physiol. 224 61–81 (1972).PubMedGoogle Scholar
  8. 8.
    B. Nielsen, S. Strange, N. J. Christensen, J. Warberg, B. Saltin, Acute and adaptive responses in humans to exercise in a warm, humid environment. Pflügers Arch. — Eur. J. Physiol. 434 49–56 (1997).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Niels Juel Christensen
    • 1
  • Peter Norsk
    • 2
  1. 1.Division of Endocrinology, Herlev HospitalUniversity of CopenhagenHerlevDenmark
  2. 2.Danish Aerospace Medical Centre of Research, National HospitalUniversity of CopenhagenDenmark

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