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Molecular Biology of Conformational Diseases

  • Claude Reiss
  • Thierry Lesnik
  • Hasan Parvez
  • Simone Parvez
  • Ricardo Ehrlich
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)

Abstract

An important family of diseases is characterized by the presence of a disease-specific protein that accumulates as “amyloid” fibers and thereby becomes toxic to the cell. Although the protein has the authentic primary sequence (except in familial cases), it adopts a non-native conformation which resists proteolysis, allowing the protein to accumulate and form fibers. Non-familial amyloid conditions are clearly epigenetic.

Keywords

Misfolded Protein Prion Disease Synonymous Codon Translation Rate Nascent Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Claude Reiss
    • 1
  • Thierry Lesnik
    • 1
  • Hasan Parvez
    • 2
  • Simone Parvez
    • 3
  • Ricardo Ehrlich
    • 4
  1. 1.Alzheim’R&DGifFrance
  2. 2.CNRS IAF GifFrance
  3. 3.Reims UniversityFrance
  4. 4.University of the RepublicMontevideo

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