Cardiac Sympathetic Imaging with Radiolabelled Metaiodobenzylguanidine (MIBG) in Patients with Parkinson’s Disease
A radiolabelled norepinephrine analogue, 123I metaiodobenzylguanidine (MIBG) has been widely used to detect cardiac sympathetic denervation or hyperactivity in cardiac diseases. Recently, cardiac 123I MIBG accumulation was reported to be significantly reduced in patients with Parkinson’s disease (PD). On the other hand, PD is known to be associated with various sympathetic disorders. Therefore, we sought to examine the relationship between severity of clinical symptoms or of autonomic dysfunction of PD and reduction of cardiac 123I MIBG accumulation.
KeywordsMultiple System Atrophy Ambulatory Blood Pressure Monitoring Multiple System Atrophy Patient Sympathetic Dysfunction Cardiac Sympathetic Denervation
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