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Cardiac Sympathetic Imaging with Radiolabelled Metaiodobenzylguanidine (MIBG) in Patients with Parkinson’s Disease

  • Hisato Takatsu
  • Kazuo Satomi
  • Hiroshi Nishida
  • Hitoshi Matsuo
  • Sachiro Watanabe
  • Kenshi Nagashima
  • Hisayoshi Fujiwara
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)

Abstract

A radiolabelled norepinephrine analogue, 123I metaiodobenzylguanidine (MIBG) has been widely used to detect cardiac sympathetic denervation or hyperactivity in cardiac diseases. Recently, cardiac 123I MIBG accumulation was reported to be significantly reduced in patients with Parkinson’s disease (PD). On the other hand, PD is known to be associated with various sympathetic disorders. Therefore, we sought to examine the relationship between severity of clinical symptoms or of autonomic dysfunction of PD and reduction of cardiac 123I MIBG accumulation.

Keywords

Multiple System Atrophy Ambulatory Blood Pressure Monitoring Multiple System Atrophy Patient Sympathetic Dysfunction Cardiac Sympathetic Denervation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Referrence

  1. 1.
    Takatsu H, et al. Cardiac Sympathetic Denervation from the Early Stage of Parkinson’s Disease -Clinical and Experimental Studies with Radiolabeled MIBG. J Nucl Med 2000; 41: 71–77.PubMedGoogle Scholar
  2. 2.
    Takatsu H, et al. Differentiating Parkinson Disease From Multiple-System Atrophy by Measuring Cardiac Iodine-123 Metaiodobenzylguanidine Accumulation. JAMA 2000 284: 44–45.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Hisato Takatsu
    • 1
  • Kazuo Satomi
  • Hiroshi Nishida
  • Hitoshi Matsuo
  • Sachiro Watanabe
  • Kenshi Nagashima
  • Hisayoshi Fujiwara
  1. 1.First Department of Internal MedicineGiru Municipal HospitalGifuJapan

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