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Models of Parkinson’s Disease

  • Makoto Naoi
  • Wakako Maruyama
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)

Abstract

Parkinson’s disease (PD) at cellular level is characterized by selective death of dopamine neurons in nigral pars compacta. The type of cell death remains an enigma, even though recent results suggest that apoptosis may be a common type of cell death. Since the discovery of a neurotoxin selective to dopamine neurons, l-methyl-4-phenyl-1, 2, 3, 6-tetrahydro-pyridine (MPTP), various types of animal and cell models have been proposed to clarify the pathogenesis of PD. In this paper, an endogenous dopaminergic neurotoxin, N-methyl-(R)salsolinol [NM(R)Sal] was used to prepare the animal and cell models, and the mechanism underlying the selective degeneration of dopamine neurons was studied. By use of the cell model, a series of (-)deprenyl (selegiline) related propargylamines showed neuroprotective functions against apoptosis induced by the neurotoxin. These results are discussed in relation to the validity of animal and cell models in the study of PD and related neurodegenerative disorders.

Keywords

Cell Model Dopamine Neuron Selective Degeneration Parkinsonian Brain Selective Death 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Makoto Naoi
    • 1
  • Wakako Maruyama
    • 2
  1. 1.Department of Brain SciencesInstitute of Applied BiochemistryGifuJapan
  2. 2.Department of Basic GerontologyNational Institute for Longevity SciencesAichiJapan

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