Advertisement

Dopamine Transporter and Parkinson’s Disease

  • Shigenobu Nakamura
  • Hideshi Kawakami
  • Hiroyuki Morino
  • Takatoshi Kawarai
  • Hiroshi Yamashita
  • Tetsuya Takahashi
  • Takako Mitsuoka
  • Yumiko Kaseda
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)

Abstract

Dopaminergic transmission is terminated by the rapid reuptake of dopamine into presynaptic nerve terminals via a dopamine transporter (DAT) localized in presynaptic cytoplasmic membranes. Since Parkinson’s disease (PD) is closely related with dopamine metabolism, we investigated the relationship between DAT and PD to develop a new therpeutic approach to the disease.

Keywords

PC12 Cell Nerve Growth Factor Nicotinic Receptor Dopamine Transporter Dopamine Uptake 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    T. Kawarai, H. Kawakami, Y. Yamamura, and S. Nakamura, Structure and organization of the gene encoding human dopamine transporter, Gene 195, 11–18 (1997).PubMedCrossRefGoogle Scholar
  2. 2.
    H. Morino, T. Kawarai, Y Izumi, T. Kazuta, M. Oda, O. Komure, F. Udaka, M. Kameyama, S. Nakamura, and H. Kawakami, A single nucleotide polymorphism of dopamine transporter gene is associated with Parkinson’s disease, Ann. Neurol. 47, 528–531 (2000).PubMedCrossRefGoogle Scholar
  3. 3.
    H. Yamashita, S. Kitayama, Y.-X. Zhang, T. Takahashi, T. Dohi, and S. Nakamura, Effect of nicotine on dopamine uptake in COS cells possessing the rat dopamine transporter and PC 12, Biochem. Pharmacol. 49, 742–745(1995).PubMedCrossRefGoogle Scholar
  4. 4.
    H. Yamashita, and S. Nakamura, Nicotine rescues PC 12 cells from death induced by nerve growth factor deprivation, Neurosci. Lett. 213, 145–147 (1996).PubMedCrossRefGoogle Scholar
  5. 5.
    T. Takahashi, H. Yamashita, S. Nakamura, H. Ishiguro, T. Nagatsu, and H. Kawakami, Effects of nerve growth factor and nicotine on the expression of nicotinic acetylcholine receptor subunits in PC 12 cells, Neurosci. Lett. 35, 175–181 (1999).Google Scholar

Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Shigenobu Nakamura
    • 1
  • Hideshi Kawakami
  • Hiroyuki Morino
  • Takatoshi Kawarai
  • Hiroshi Yamashita
  • Tetsuya Takahashi
  • Takako Mitsuoka
  • Yumiko Kaseda
    • 1
  1. 1.Hiroshima UniversityHiroshimaJapan

Personalised recommendations