Polymer-Based Compounds for Targeted Imaging
The ultimate aim of all targeted imaging is to achieve a large contrast enhancement at the diseased sites that offers not only anatomical but also functional and physicobiochemical information noninvasively. Thus, in this respect, targeted imaging is very similar to drug targeting where the goal is to treat the diseased condition without harming the host, that is, to achieve a large therapeutic index. Depending on the size of contrast agents, two distinct approaches can be envisaged: (1) the agent has low molecular weight (usually <1000 Da); (2) the agent has high molecular weight, or large size, and localization of the agent to the tumor is mediated by carriers that include particulate, liposomal, and macromolecular contrast agents. The latter approach can be further subclassified into passive targeting and active targeting.
KeywordsContrast Agent Tumor Uptake Magn Reson Image Magnetic Resonance Imaging Contrast Agent Passive Target
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- 19.Bagnodav AA, Weissleder R, Frank HW, et al. A new macromolecule as a contrast agent for MR angiography: preparation, properties, and animal studies. Radiology 1993;187:701–706.Google Scholar
- 24.Weinmann HJ, Ebert W, Wagner S, et al. MR angio with special focus on blood pool agents. In: Proceedings of the IX International Workshop on Magnetic Resonance Angiography, Valencia, October 7–11,1997, pp 335–340.Google Scholar
- 35.Neuwelt EA, Remsen LG, McCormick CI, et al. Magnetic resonance imaging of monocrystalline iron oxide nanocompound conjugated carcinoma specific monocloncal antibody in a rodent model of intracerebral human lung cancer: the potential for knifeless diagnosis. Proc Am Assoc Cancer Res 1995;36:483.Google Scholar
- 47.Prim MV, Perkins AC, Duncan R, et al. Targeting of N-(2-hydroxylpropyl)methacrylamide copolymer-doxyrubicin conjugate to the hepatocyte galactose-receptor in mice: visualization and quantification by gamma scintigraphy as a basis for clinical targeting studies. J Drug Targeting 1993;1:125–131.CrossRefGoogle Scholar
- 49.Li C, Newman RA, Wu Q-P, et al. Biodistribution of paclitaxel and poly (L-glutamic-acid)-paclitaxel conjugates in mice with ovarian OCa-1 tumor. Cancer Chemother Pharmacol, in press.Google Scholar