Peptide Receptor Imaging
Peptides are small number (<50) of units of amino acids covalently linked by the peptide bond. They are smaller in size and lower in molecular weight (<10,000 daltons) than proteins. Peptides also lack tertiary structures. Therefore, they are less prone to immunogenicity. Because target-specific imaging using monoclonal antibodies has proven elusive, imaging using biologically active peptides has raised enthusiasm among scientists and clinicians. This interest is because of the wealth of molecular recognition technology and protein biochemistry that may be applied to the diagnosis of human disease by direct visualization of the specific disease sites. This technology has become possible with the recent advances in imaging devices, protein chemistry, and the understanding of the physiological and pathological roles of protein and peptides.
KeywordsPositron Emission Tomography Vasoactive Intestinal Peptide Receptor Imaging Solitary Pulmonary Nodule Molecular Recognition Technology
Unable to display preview. Download preview PDF.
- 2.Yalow RS, Berson SA. Basic considerations and general considerations. In: Odele WD, Daughaday WH, eds. Principles of Competitive Protein Binding Assays. Philadelphia: Lippincott,1971:1.Google Scholar
- 3.Wong FCL, Ho B, Lu IG, et al. Affinity labeling of neuroreceptors using gamma rays. J Nucl Med 1993;34(5):26 (abstract).Google Scholar
- 6.Wong DF, Pearlson G, Tune LE, et al. In vivo measurements of D2 dopamine receptor abnormalities in drug-naive and treated manic depressive patients. J Nucl Med 1987;28:611 (abstract).Google Scholar
- 8.Eckelman WC. The testing of putative receptor binding radiotracers in vivo. In: Diksic M, Reba RD, eds. Radiopharmaceuticals and Brain Pathology Studies with PET and SPECT. Boca Raton: CRC Press, 1982:42–62.Google Scholar
- 10.Yung BCK, Wand GS, Blevins L, et al. In vivo assessment of dopamine receptor density in pituitary macroadenoma and correlation with in vitro assay. J Nucl Med 1993;34(5):133 (abstract).Google Scholar
- 20.Krenning EP, Kwekkeboom DJ, Panwels S, et al. Somatostatin receptor scintigraphy. Nucl Med Ann 1995;15:1–50.Google Scholar