Imaging of Gene Delivery and Expression
Recent advances in cell biology and genetic engineering have led to the identification of genes that control many disease states, including cancer, cystic fibrosis, sickle cell anemia, AIDS, and Parkinson’s disease. These discoveries have led to an increased understanding of the fundamental mechanisms of disease and to the development of genetically based therapies. Although new genes are being identified at the rate of approximately one new gene per day and progress is being made in the use of new gene therapies in animal studies and clinical trials, the primary method to test for gene expression involves tissue analysis. Tissue analysis is expensive, time consuming, painful, and subject to sampling errors. Only recently it has been possible to determine noninvasively if exogenous genes are being delivered to the diseased sites and if the exogenous protein is being expressed.
KeywordsSingle Photon Emission Compute Tomography Gene Therapy Gene Delivery Herpes Simplex Virus Type Thymidine Kinase
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