Abstract
The number of subjects is an important design parameter in clinical trials. The key information when planning the sample size is the postulated effect and its variation. The effect size may come from prior trials, from literature review, or quite often from the best guess by the investigator.
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Wang, W., Krause, A. (2001). Sample Size Reestimation. In: Millard, S.P., Krause, A. (eds) Applied Statistics in the Pharmaceutical Industry. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-3466-9_15
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DOI: https://doi.org/10.1007/978-1-4757-3466-9_15
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